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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2006-12-5
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pubmed:abstractText |
A global scan of transcription factor usage in the sea urchin embryo was carried out in the context of the Strongylocentrotus purpuratus genome sequencing project, and results from six individual studies are here considered. Transcript prevalence data were obtained for over 280 regulatory genes encoding sequence-specific transcription factors of every known family, but excluding genes encoding zinc finger proteins. This is a statistically inclusive proxy for the total "regulome" of the sea urchin genome. Close to 80% of the regulome is expressed at significant levels by the late gastrula stage. Most regulatory genes must be used repeatedly for different functions as development progresses. An evolutionary implication is that animal complexity at the stage when the regulome first evolved was far simpler than even the last common bilaterian ancestor, and is thus of deep antiquity.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/17101125-10781044,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17101125-11023866,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17101125-11171388,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17101125-11179890,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17101125-11543524,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17101125-11714666,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17101125-11872831,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17101125-12027440,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17101125-12070079,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17101125-12883007,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17101125-12941621,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17101125-12949122,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17101125-14603324,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17101125-15084738,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17101125-15128674,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17101125-15178752,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17101125-15196954,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17101125-15223347,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17101125-15261650,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17101125-15328009,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17101125-15494441,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17101125-15788537,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17101125-15795378,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17101125-15893979,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17101125-15936326,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17101125-15983372,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17101125-16198288,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17101125-16581059,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17101125-16778054,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17101125-2187672,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17101125-3192074,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17101125-9230695,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17101125-9789041
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0012-1606
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
300
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
27-34
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pubmed:dateRevised |
2011-9-26
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pubmed:meshHeading |
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pubmed:year |
2006
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pubmed:articleTitle |
High regulatory gene use in sea urchin embryogenesis: Implications for bilaterian development and evolution.
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pubmed:affiliation |
Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.,
Review,
Research Support, N.I.H., Extramural
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