17100573

Source:http://linkedlifedata.com/resource/pubmed/id/17100573

Download in:

Switch to

Custom View

Named Graph Language Inference

Statements in which the resource exists as a subject.
Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0920472, umls-concept:C1335073, umls-concept:C1521840, umls-concept:C1551022, umls-concept:C1961136
pubmed:issue	9
pubmed:dateCreated	2006-11-14
pubmed:abstractText	To date, the pharmaceutical industry has placed a considerable amount of interest in the discovery of drug targets and diagnostics. One of the most challenging areas of drug discovery today is the search for novel receptor-ligand pairs. Nuclear receptors comprise a large superfamily of ligand-dependent transcription factors that regulate the expression of genes critical for a variety of biological processes, including development, growth, differentiation, and homeostasis. Orphan nuclear receptors, for which the ligands are not yet identified, represent the most ancient component of the nuclear receptor superfamily. Orphan nuclear receptors not only offer a unique system to uncover novel signaling pathways that impact human health, but also provide excellent targets of drug discoveries for a variety of human diseases. This review highlights advances made on ligand identification for orphan nuclear receptors using transgenic mouse models, cell-based screening, direct binding, structure-based assays, and computer-aided virtual screening. With rapid advances in combinatorial chemistry and high throughput screening, along with other modern technologies, this field promises a bountiful harvest.
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/9810948
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Cytoplasmic and Nuclear
pubmed:status	MEDLINE
pubmed:month	Nov
pubmed:issn	1386-2073
pubmed:author	pubmed-author:ShiYanhongY
pubmed:issnType	Print
pubmed:volume	9
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	683-9
pubmed:meshHeading	pubmed-meshheading:17100573-Animals, pubmed-meshheading:17100573-Drug Design, pubmed-meshheading:17100573-Mice, pubmed-meshheading:17100573-Mice, Transgenic, pubmed-meshheading:17100573-Molecular Structure, pubmed-meshheading:17100573-Receptors, Cytoplasmic and Nuclear
pubmed:year	2006
pubmed:articleTitle	Orphan nuclear receptors, excellent targets of drug discovery.
pubmed:affiliation	Division of Neurosciences, Center for Gene Expression and Drug Discovery, Beckman Research Institute of City of Hope National Medical Center, 1500 E. Duarte Road, Duarte, CA 91010, USA. yshi@coh.org
pubmed:publicationType	Journal Article, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural