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rdf:type |
|
|
lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2007-2-19
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pubmed:abstractText |
Recurrent miscarriage (RM) has been suggested to be caused by mutations in genes coding for various coagulation factors resulting in thrombophilia. Mouse models indicate that genes involved in the protein C anticoagulant pathway are essential for normal embryonic development. Loss of function of two of these genes, thrombomodulin (TM) and endothelial protein C receptor (EPCR), causes embryonic lethality in mice. The aim of this study was to determine whether variations in the human TM or EPCR genes are associated with an increased risk for RM.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
|
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0268-1161
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:volume |
22
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
864-8
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:17099210-3' Untranslated Regions,
pubmed-meshheading:17099210-Abortion, Habitual,
pubmed-meshheading:17099210-Adolescent,
pubmed-meshheading:17099210-Adult,
pubmed-meshheading:17099210-Antigens, CD,
pubmed-meshheading:17099210-Chromatography, High Pressure Liquid,
pubmed-meshheading:17099210-Female,
pubmed-meshheading:17099210-Genetic Variation,
pubmed-meshheading:17099210-Humans,
pubmed-meshheading:17099210-Mutation,
pubmed-meshheading:17099210-Pregnancy,
pubmed-meshheading:17099210-Receptors, Cell Surface,
pubmed-meshheading:17099210-Thrombomodulin
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pubmed:year |
2007
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pubmed:articleTitle |
Variations in the thrombomodulin and endothelial protein C receptor genes in couples with recurrent miscarriage.
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pubmed:affiliation |
Folkhälsan Institute of Genetics, University of Helsinki, Finland.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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