rdf:type |
|
lifeskim:mentions |
umls-concept:C0007634,
umls-concept:C0010739,
umls-concept:C0034788,
umls-concept:C0108773,
umls-concept:C0441471,
umls-concept:C1280500,
umls-concept:C1332714,
umls-concept:C1367475,
umls-concept:C1514485,
umls-concept:C1523873,
umls-concept:C1879547,
umls-concept:C2349975
|
pubmed:issue |
11
|
pubmed:dateCreated |
1991-6-25
|
pubmed:abstractText |
Cytochalasins are known to inhibit or enhance the proliferation of T cells induced by mitogens in a concentration-dependent fashion. To clarify the mechanism by which cytochalasins enhance T cell proliferation, we examined which activation pathways and events in signal transduction were affected by cytochalasins. We also examined subsets of CD4 cells for a preferential response to cytochalasins. Cytochalasins enhanced the proliferation of CD4 cells induced by optimal doses of anti-CD3 antibody or suboptimal doses of anti-CD2 antibodies. Cytochalasins, at low concentrations, enhanced the rise in intracellular Ca2+ and production of IP3 in CD4 cells activated by anti-CD2 or CD3 antibodies. Cytochalasins also enhanced the modulation of CD3 induced by anti-CD3 antibody. These results suggest that cytochalasins enhance the proliferation of CD4 cells by affecting early events in signal transduction after activation through the CD3-Ti Ag-receptor complex or CD2 molecule. At the doses used, cytochalasins appear to interact with cytochalasin-binding sites in the cell membrane. Cytochalasins predominantly enhanced CD3-mediated proliferation in the CD29-subset of CD4 cells.
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
AIM
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD2,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD29,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD3,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD4,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Differentiation...,
http://linkedlifedata.com/resource/pubmed/chemical/Calcium,
http://linkedlifedata.com/resource/pubmed/chemical/Cytochalasins,
http://linkedlifedata.com/resource/pubmed/chemical/Inositol Phosphates,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Antigen, T-Cell,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Immunologic
|
pubmed:status |
MEDLINE
|
pubmed:month |
Jun
|
pubmed:issn |
0022-1767
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:day |
1
|
pubmed:volume |
146
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
3736-41
|
pubmed:dateRevised |
2004-11-17
|
pubmed:meshHeading |
pubmed-meshheading:1709660-Antigens, CD,
pubmed-meshheading:1709660-Antigens, CD2,
pubmed-meshheading:1709660-Antigens, CD29,
pubmed-meshheading:1709660-Antigens, CD3,
pubmed-meshheading:1709660-Antigens, CD4,
pubmed-meshheading:1709660-Antigens, Differentiation, T-Lymphocyte,
pubmed-meshheading:1709660-Calcium,
pubmed-meshheading:1709660-Cytochalasins,
pubmed-meshheading:1709660-Humans,
pubmed-meshheading:1709660-Inositol Phosphates,
pubmed-meshheading:1709660-Lymphocyte Activation,
pubmed-meshheading:1709660-Receptors, Antigen, T-Cell,
pubmed-meshheading:1709660-Receptors, Immunologic,
pubmed-meshheading:1709660-T-Lymphocytes
|
pubmed:year |
1991
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pubmed:articleTitle |
Cytochalasins enhance the proliferation of CD4 cells through the CD3-Ti antigen receptor complex or the CD2 molecule through an effect on early events of activation.
|
pubmed:affiliation |
Second Department of Internal Medicine, Saitama Medical Center, Saitama Medical School, Kawagoe City, Japan.
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pubmed:publicationType |
Journal Article
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