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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2007-5-28
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pubmed:abstractText |
Osteosarcoma (OS) has been well described in individuals with germ-line TP53 mutations (Li-Fraumeni Syndrome) but typically occurs sporadically in adolescents and young adults. Single nucleotide polymorphisms (SNPs), the most common germ-line genetic variation, have been associated with risk for other types of cancer. We hypothesized that genetic variation in TP53 could be associated with OS risk based on its critical role in cell growth and effect of somatic mutations in OS tumors.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
1545-5009
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
49
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
28-33
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pubmed:dateRevised |
2009-1-12
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pubmed:meshHeading |
pubmed-meshheading:17096406-Adolescent,
pubmed-meshheading:17096406-Adult,
pubmed-meshheading:17096406-Aged,
pubmed-meshheading:17096406-Bone Neoplasms,
pubmed-meshheading:17096406-Case-Control Studies,
pubmed-meshheading:17096406-Child,
pubmed-meshheading:17096406-Child, Preschool,
pubmed-meshheading:17096406-Female,
pubmed-meshheading:17096406-Genetic Variation,
pubmed-meshheading:17096406-Germ-Line Mutation,
pubmed-meshheading:17096406-Humans,
pubmed-meshheading:17096406-Male,
pubmed-meshheading:17096406-Middle Aged,
pubmed-meshheading:17096406-Osteosarcoma,
pubmed-meshheading:17096406-Polymorphism, Single Nucleotide,
pubmed-meshheading:17096406-Prognosis,
pubmed-meshheading:17096406-Tumor Suppressor Protein p53
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pubmed:year |
2007
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pubmed:articleTitle |
Germ-line genetic variation of TP53 in osteosarcoma.
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pubmed:affiliation |
Pediatric Oncology Branch, CCR, NCI, NIH, Bethesda, Maryland. savagesh@mail.nih.gov
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
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