Source:http://linkedlifedata.com/resource/pubmed/id/17096315
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
4
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pubmed:dateCreated |
2006-11-19
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pubmed:abstractText |
Serous borderline tumours (SBTs) of the ovary were originally classified as such because the vast majority behave in a remarkably indolent manner, even in the presence of widespread tumour deposits, termed implants, and/or lymph node involvement. The pathogenesis of the implants is currently unknown. Two major hypotheses have been proposed: the first favours a monoclonal origin, arguing that the peritoneal lesions derive from neoplastic cells that are shed from the primary ovarian tumour. The second hypothesis favours a polyclonal origin as a result of a field defect of susceptible Müllerian cells from which multiple independent tumours arise. To test both hypotheses, genome-wide allelotyping and B-RAF/K-RAS mutation analyses were employed to assess clonality in 25 metachronous or synchronous tumours from ten SBT patients. Loss of heterozygosity (LOH) profiling and K-RAS/B-RAF mutation analysis showed concordance of the genetic changes in all sites in 21 tumours from eight patients who were informative. These results favour a common origin, underscored by a likelihood ratio (probability of common origin/probability of independent origin) ranging from 2.43 to 7,662,850. In conclusion, this study strongly supports the hypothesis that both non-invasive and invasive implants arise as a consequence of spread from a single ovarian site.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0022-3417
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
210
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
405-11
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:17096315-DNA Mutational Analysis,
pubmed-meshheading:17096315-Female,
pubmed-meshheading:17096315-Genes, ras,
pubmed-meshheading:17096315-Genotype,
pubmed-meshheading:17096315-Humans,
pubmed-meshheading:17096315-Loss of Heterozygosity,
pubmed-meshheading:17096315-Microsatellite Repeats,
pubmed-meshheading:17096315-Mutation,
pubmed-meshheading:17096315-Neoplasm Invasiveness,
pubmed-meshheading:17096315-Neoplasm Proteins,
pubmed-meshheading:17096315-Neoplasm Staging,
pubmed-meshheading:17096315-Ovarian Neoplasms,
pubmed-meshheading:17096315-Peritoneal Neoplasms,
pubmed-meshheading:17096315-Peritoneum,
pubmed-meshheading:17096315-Proto-Oncogene Proteins B-raf
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pubmed:year |
2006
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pubmed:articleTitle |
Clonal analysis favours a monoclonal origin for serous borderline tumours with peritoneal implants.
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pubmed:affiliation |
Department of Pathology, University of Maastricht, The Netherlands.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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