Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2007-3-9
pubmed:abstractText
We used a congenic C57Bl/6J cystic fibrosis transmembrane conductance regulator (Cftr)(-/-) mouse model, which develops cystic fibrosis (CF)-like pathology in all organs, to evaluate the short- and long-term therapeutic effects of dietary docosahexaenoic acid (DHA). Thirty-day-old Cftr(-/-) mice and wild-type littermates were randomized to receive a liquid diet with or without DHA (40 mg/day). Animals were killed for histological and lipid analysis after 7, 30, and 60 days of therapy. DHA had no significant therapeutic or harmful effect on the lung, pancreas, or ileum of the Cftr(-/-) mice or their wild-type littermates. In contrast, dietary DHA resulted in highly significant amelioration of the severity of liver disease in the Cftr(-/-) mice, primarily a reduction in the degree of peri-portal inflammation. Additionally, these detailed measurements confirm our previous findings that Cftr(-/-) mice have significant alterations in the pancreas (except external acinar diameter), ileum, liver, lung, and salivary (except sublingual) glands at all ages compared with their age-matched wild-type littermates. In conclusion, inhibition of cytokines and/or eicosanoid metabolism and release of endogenous inhibitors of inflammation by DHA may account for the anti-inflammatory effects in the liver of this congenic murine model of CF. The potential therapeutic benefits of DHA in severe CF-associated liver disease remain to be explored.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0193-1857
pubmed:author
pubmed:issnType
Print
pubmed:volume
292
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
G839-48
pubmed:dateRevised
2007-12-3
pubmed:meshHeading
pubmed-meshheading:17095751-Administration, Oral, pubmed-meshheading:17095751-Age Factors, pubmed-meshheading:17095751-Animals, pubmed-meshheading:17095751-Arachidonic Acid, pubmed-meshheading:17095751-Bile Ducts, pubmed-meshheading:17095751-Cystic Fibrosis, pubmed-meshheading:17095751-Disease Models, Animal, pubmed-meshheading:17095751-Docosahexaenoic Acids, pubmed-meshheading:17095751-Erythrocytes, pubmed-meshheading:17095751-Ileum, pubmed-meshheading:17095751-Liver, pubmed-meshheading:17095751-Lung, pubmed-meshheading:17095751-Mice, pubmed-meshheading:17095751-Mice, Congenic, pubmed-meshheading:17095751-Mice, Inbred C57BL, pubmed-meshheading:17095751-Mice, Inbred CFTR, pubmed-meshheading:17095751-Pancreas, pubmed-meshheading:17095751-Random Allocation, pubmed-meshheading:17095751-Salivary Glands, pubmed-meshheading:17095751-Treatment Outcome
pubmed:year
2007
pubmed:articleTitle
Long-term docosahexaenoic acid therapy in a congenic murine model of cystic fibrosis.
pubmed:affiliation
Program in Integrative Biology, The Research Institute, Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural