| pubmed-article:17095647 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17095647 | lifeskim:mentions | umls-concept:C0178784 | lld:lifeskim |
| pubmed-article:17095647 | lifeskim:mentions | umls-concept:C0205108 | lld:lifeskim |
| pubmed-article:17095647 | lifeskim:mentions | umls-concept:C0128897 | lld:lifeskim |
| pubmed-article:17095647 | lifeskim:mentions | umls-concept:C1819426 | lld:lifeskim |
| pubmed-article:17095647 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:17095647 | lifeskim:mentions | umls-concept:C1883709 | lld:lifeskim |
| pubmed-article:17095647 | lifeskim:mentions | umls-concept:C1743827 | lld:lifeskim |
| pubmed-article:17095647 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:17095647 | pubmed:dateCreated | 2007-3-7 | lld:pubmed |
| pubmed-article:17095647 | pubmed:abstractText | Leukocyte infiltration, mediated by chemokines, is a key step in the development of organ dysfunction. Lung and liver neutrophil infiltration following trauma-hemorrhage is associated with upregulation of monocyte chemoattractant protein-1 (MCP-1). Because MCP-1 is not a major attractant for neutrophils, we hypothesized that MCP-1 influences neutrophil infiltration via regulation of keratinocyte-derived chemokines (KC). To study this, male C3H/HeN mice were pretreated with MCP-1 antiserum or control serum and subjected to trauma-hemorrhage or sham operation. Animals were killed 4 h after resuscitation. One group of trauma-hemorrhage mice receiving MCP-1 antiserum was also treated with murine KC during resuscitation. Plasma levels and tissue content of MCP-1 and KC were determined by cytometric bead arrays. Immunohistochemistry was performed to determine neutrophil infiltration; organ damage was assessed by edema formation. Treatment with MCP-1 antiserum significantly decreased systemic, lung, and liver levels of MCP-1 and KC following trauma-hemorrhage. This decrease in MCP-1 levels was associated with decreased neutrophil infiltration and edema formation in lung and liver following trauma-hemorrhage. Restitution of KC in mice treated with MCP-1 antiserum restored tissue neutrophil infiltration and edema. These results lead us to conclude that increased levels of MCP-1 cause neutrophil accumulation and distant organ damage by regulating KC production during the postinjury inflammatory response. | lld:pubmed |
| pubmed-article:17095647 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17095647 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17095647 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17095647 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17095647 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:17095647 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17095647 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17095647 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17095647 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:17095647 | pubmed:issn | 0363-6119 | lld:pubmed |
| pubmed-article:17095647 | pubmed:author | pubmed-author:SchwachaMarti... | lld:pubmed |
| pubmed-article:17095647 | pubmed:author | pubmed-author:ChaudryIrshad... | lld:pubmed |
| pubmed-article:17095647 | pubmed:author | pubmed-author:KunkelSteven... | lld:pubmed |
| pubmed-article:17095647 | pubmed:author | pubmed-author:HsiehYa-Ching... | lld:pubmed |
| pubmed-article:17095647 | pubmed:author | pubmed-author:FrinkMichaelM | lld:pubmed |
| pubmed-article:17095647 | pubmed:author | pubmed-author:ChoudhryMashk... | lld:pubmed |
| pubmed-article:17095647 | pubmed:author | pubmed-author:LuAilingA | lld:pubmed |
| pubmed-article:17095647 | pubmed:author | pubmed-author:ThobeBjoern... | lld:pubmed |
| pubmed-article:17095647 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17095647 | pubmed:volume | 292 | lld:pubmed |
| pubmed-article:17095647 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17095647 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17095647 | pubmed:pagination | R1110-6 | lld:pubmed |
| pubmed-article:17095647 | pubmed:dateRevised | 2007-12-3 | lld:pubmed |
| pubmed-article:17095647 | pubmed:meshHeading | pubmed-meshheading:17095647... | lld:pubmed |
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| pubmed-article:17095647 | pubmed:meshHeading | pubmed-meshheading:17095647... | lld:pubmed |
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| pubmed-article:17095647 | pubmed:meshHeading | pubmed-meshheading:17095647... | lld:pubmed |
| pubmed-article:17095647 | pubmed:meshHeading | pubmed-meshheading:17095647... | lld:pubmed |
| pubmed-article:17095647 | pubmed:meshHeading | pubmed-meshheading:17095647... | lld:pubmed |
| pubmed-article:17095647 | pubmed:meshHeading | pubmed-meshheading:17095647... | lld:pubmed |
| pubmed-article:17095647 | pubmed:meshHeading | pubmed-meshheading:17095647... | lld:pubmed |
| pubmed-article:17095647 | pubmed:meshHeading | pubmed-meshheading:17095647... | lld:pubmed |
| pubmed-article:17095647 | pubmed:meshHeading | pubmed-meshheading:17095647... | lld:pubmed |
| pubmed-article:17095647 | pubmed:meshHeading | pubmed-meshheading:17095647... | lld:pubmed |
| pubmed-article:17095647 | pubmed:meshHeading | pubmed-meshheading:17095647... | lld:pubmed |
| pubmed-article:17095647 | pubmed:meshHeading | pubmed-meshheading:17095647... | lld:pubmed |
| pubmed-article:17095647 | pubmed:year | 2007 | lld:pubmed |
| pubmed-article:17095647 | pubmed:articleTitle | Monocyte chemoattractant protein-1 influences trauma-hemorrhage-induced distal organ damage via regulation of keratinocyte-derived chemokine production. | lld:pubmed |
| pubmed-article:17095647 | pubmed:affiliation | Center for Surgical Research and Department of Surgery, University of Alabama at Birmingham, Volker Hall-Suite G094, 1670 University Blvd., Birmingham, AL 35294-0019, USA. | lld:pubmed |
| pubmed-article:17095647 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:17095647 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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