Linked Life Data

17095594

Source:http://linkedlifedata.com/resource/pubmed/id/17095594

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2007-1-17
pubmed:databankReference
pubmed:abstractText
The prolactin (PRL) family of hormones/cytokines is involved in the maintenance of pregnancy and adaptations to physiological stressors. In this report, we identify and characterize a new member of the rat PRL family, examine the impact of maternal hypoxia on placental PRL family gene expression, and investigate maternal adaptive responses to hypoxia. Perusal of the PRL gene family locus in the rat genome resulted in the identification of a putative new member of the rat PRL family. The new member is closely related to the previously reported PRL-like protein-F (PLP-F) and has been named PLP-Fbeta and the originally characterized PLP-F, now termed PLP-Falpha. The two proteins exhibit structural similarities but possess distinct cell- and temporal-specific expression profiles. In vivo hypoxia stimulates placental PLP-Falpha and PLP-E mRNA expression in the rat and mouse, respectively. Rcho-1 trophoblast cells can differentiate into trophoblast giant cells, express PLP-Falpha, and exhibit enhanced PLP-Falpha mRNA levels when cultured under low oxygen tension (2%). Exposure to hypobaric hypoxia during latter part of pregnancy did not significantly impact the expression of PLP-Fbeta mRNA. Finally, exposure to hypobaric hypoxia during midpregnancy led to increased maternal red blood cells, hemoglobin concentrations, hematocrit, and increased concentrations of maternal splenic mRNAs for key proteins involved in hemoglobin synthesis, erythroid Krüppel-like factor, erythroid 5-aminolevulinate synthase-2, and beta-major globin. In summary, adaptive responses to maternal hypoxia include activation of placental PLP-Falpha/E gene expression, which may then participate in maternal hematological adjustments required for maintaining maternal and fetal oxygen delivery.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0013-7227
pubmed:author
pubmed:issnType
Print
pubmed:volume
148
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
559-65
pubmed:dateRevised
2007-12-3
pubmed:meshHeading
pubmed-meshheading:17095594-Adaptation, Physiological, pubmed-meshheading:17095594-Amino Acid Sequence, pubmed-meshheading:17095594-Animals, pubmed-meshheading:17095594-Anoxia, pubmed-meshheading:17095594-Cell Line, pubmed-meshheading:17095594-Cytokines, pubmed-meshheading:17095594-Erythrocyte Count, pubmed-meshheading:17095594-Female, pubmed-meshheading:17095594-Gene Expression, pubmed-meshheading:17095594-Glycoproteins, pubmed-meshheading:17095594-Hematocrit, pubmed-meshheading:17095594-Hemoglobins, pubmed-meshheading:17095594-Male, pubmed-meshheading:17095594-Mice, pubmed-meshheading:17095594-Mice, Inbred Strains, pubmed-meshheading:17095594-Molecular Sequence Data, pubmed-meshheading:17095594-Oxygen, pubmed-meshheading:17095594-Placental Hormones, pubmed-meshheading:17095594-Pregnancy, pubmed-meshheading:17095594-Pregnancy Complications, pubmed-meshheading:17095594-Pregnancy Proteins, pubmed-meshheading:17095594-Protein Isoforms, pubmed-meshheading:17095594-RNA, Messenger, pubmed-meshheading:17095594-Rats, pubmed-meshheading:17095594-Rats, Inbred Strains, pubmed-meshheading:17095594-Trophoblasts
pubmed:year
2007
pubmed:articleTitle
Prolactin-like protein-f subfamily of placental hormones/cytokines: responsiveness to maternal hypoxia.
pubmed:affiliation
Institute of Maternal-Fetal Biology, Division of Cancer and Developmental Biology, Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, Kansas 66160, USA.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural