Linked Life Data

17095216

Source:http://linkedlifedata.com/resource/pubmed/id/17095216

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2007-1-15
pubmed:abstractText
The pyrrole-imidazole alkaloid rac-dibromophakellstatin displayed selective antitumor activity in vitro when tested in 36 cell lines in a cell survival and proliferation assay. The ovarian cancer cell line OVXF 899L proved to be most sensitive (0.60 microM, IC50), followed by the glioblastoma cell line CNXF 498NL (0.93 microM), the non-small lung cancer cell line LXF 529L (0.96 microM), and the uterus cancer cell line UXF 1138L (1.21 microM). The selectivity profile of rac-dibromophakellstatin may be indicative for a novel mechanism of action. Separation of the enantiomers on a chiral HPLC column revealed that only the naturally occurring (-)-dibromophakellstatin is antitumor active. Debromination of the pyrrole moiety leads to complete loss of activity.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0960-894X
pubmed:author
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
17
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
346-9
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
Antitumor activity of the marine natural product dibromophakellstatin in vitro.
pubmed:affiliation
Ludwig Maximilian University, Department of Chemistry and Biochemistry, Butenandtstr. 5-13, 81377 Munich, Germany.
pubmed:publicationType
Journal Article