Linked Life Data

17094963

Source:http://linkedlifedata.com/resource/pubmed/id/17094963

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2006-11-28
pubmed:abstractText
In glaucoma, there is atrophy and loss of retinal ganglion cells (RGC), in addition to atrophy and loss of target neurons in the lateral geniculate nucleus (LGN) of the brain. To investigate possible changes to the dendrites of LGN neurons in glaucoma, a selective marker for dendrites called microtubule-associated protein-2 (MAP2) was used. The LGNs from five monkeys with varying degrees of optic nerve fiber loss were compared to those from five normal control monkeys. Dendrites in magno- and parvocellular layers connected to the glaucomatous eye were evaluated. In controls, long MAP2-positive dendrites with multiple fine branches were seen. However, chronic ocular hypertension induced striking disruption of dendrites with a thickened and shortened appearance. Dendrite field area was significantly reduced in the glaucoma group compared to controls. Sholl analysis revealed reduced dendrite complexity by 47% and 41% in magnocellular layer 1 and parvocellular layer 6, respectively in the glaucoma group compared to controls. The striking dendrite changes in the LGN following chronically elevated intraocular pressure may be relevant to early visual dysfunction in glaucoma.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0014-4835
pubmed:author
pubmed:issnType
Print
pubmed:volume
84
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
176-84
pubmed:dateRevised
2010-12-3
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
Chronic ocular hypertension induces dendrite pathology in the lateral geniculate nucleus of the brain.
pubmed:affiliation
Glaucoma and Nerve Protection Unit, St. Michael's Hospital, University of Toronto, Canada.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural