| pubmed-article:17094804 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17094804 | lifeskim:mentions | umls-concept:C0032520 | lld:lifeskim |
| pubmed-article:17094804 | lifeskim:mentions | umls-concept:C0025723 | lld:lifeskim |
| pubmed-article:17094804 | lifeskim:mentions | umls-concept:C0936012 | lld:lifeskim |
| pubmed-article:17094804 | lifeskim:mentions | umls-concept:C1705938 | lld:lifeskim |
| pubmed-article:17094804 | lifeskim:mentions | umls-concept:C1527178 | lld:lifeskim |
| pubmed-article:17094804 | pubmed:dateCreated | 2006-11-22 | lld:pubmed |
| pubmed-article:17094804 | pubmed:abstractText | DNA methylation plays an important role in development and tumorigenesis by epigenetic modification and silencing of critical genes. The development of PCR-based methylation assays on bisulphite modified DNA heralded a breakthrough in speed and sensitivity for gene methylation analysis. Despite this technological advancement, these approaches require a cumbersome gene by gene primer design and experimental validation. Bisulphite DNA modification results in sequence alterations (all unmethylated cytosines are converted into uracils) and a general sequence complexity reduction as cytosines become underrepresented. Consequently, standard BLAST sequence homology searches cannot be applied to search for specific methylation primers. | lld:pubmed |
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| pubmed-article:17094804 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17094804 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17094804 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:17094804 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17094804 | pubmed:issn | 1471-2105 | lld:pubmed |
| pubmed-article:17094804 | pubmed:author | pubmed-author:De PaepeAnneA | lld:pubmed |
| pubmed-article:17094804 | pubmed:author | pubmed-author:SpelemanFrank... | lld:pubmed |
| pubmed-article:17094804 | pubmed:author | pubmed-author:VandesompeleJ... | lld:pubmed |
| pubmed-article:17094804 | pubmed:author | pubmed-author:PattynFilipF | lld:pubmed |
| pubmed-article:17094804 | pubmed:author | pubmed-author:HoebeeckJasmi... | lld:pubmed |
| pubmed-article:17094804 | pubmed:author | pubmed-author:RobbrechtPiet... | lld:pubmed |
| pubmed-article:17094804 | pubmed:author | pubmed-author:MichelsEviE | lld:pubmed |
| pubmed-article:17094804 | pubmed:author | pubmed-author:BottuGuyG | lld:pubmed |
| pubmed-article:17094804 | pubmed:author | pubmed-author:CoornaertDavi... | lld:pubmed |
| pubmed-article:17094804 | pubmed:author | pubmed-author:HerzogRobertR | lld:pubmed |
| pubmed-article:17094804 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:17094804 | pubmed:volume | 7 | lld:pubmed |
| pubmed-article:17094804 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17094804 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17094804 | pubmed:pagination | 496 | lld:pubmed |
| pubmed-article:17094804 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:17094804 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:17094804 | pubmed:articleTitle | methBLAST and methPrimerDB: web-tools for PCR based methylation analysis. | lld:pubmed |
| pubmed-article:17094804 | pubmed:affiliation | Center for Medical Genetics, Ghent University Hospital, De Pintelaan 185, 9000 Ghent, Belgium. Filip.Pattyn@UGent.be <Filip.Pattyn@UGent.be> | lld:pubmed |
| pubmed-article:17094804 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:17094804 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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