Linked Life Data

17094142

Source:http://linkedlifedata.com/resource/pubmed/id/17094142

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2007-3-5
pubmed:abstractText
Prophylactic efficacy of topical microbicidal drug delivery formulations against HIV may depend upon their abilities to coat and be retained on epithelial surfaces where infection begins. Rheological and surface properties play paramount roles in governing coating. While fundamental fluid mechanical studies of epithelial coating mechanisms have begun, their results have not previously addressed questions of practical value to formulators in the pharmaceutics community. The present theoretical study began this process. We focused upon squeezing flows of seven vaginal gels which are models for future microbicides or a candidate formulation in clinical trials. Each formulation is based upon one of three different macromolecules: cellulose, polyacrylic acid (PAA), or carrageenan. We addressed: (1) properties with greatest influence on squeezing flow; (2) alterations of properties to improve measures of coating dynamics; and (3) effects of polymer concentration and temperature on coating dynamics. We found that yield stresses dominated flows of PAA gels, and that surface slip, while small, significantly influenced coating by cellulose gels. Decreases in consistency, increases in shear-thinning, and increases in temperature led to thinner coatings. Details of altered coating rates depended upon parameter values and time. Specific polymer concentration effects differed between cellulose and PAA gels, though trends were similar.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0022-3549
pubmed:author
pubmed:copyrightInfo
(c) 2006 Wiley-Liss, Inc.
pubmed:issnType
Print
pubmed:volume
96
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
835-50
pubmed:dateRevised
2007-12-3
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
Interpreting properties of microbicide drug delivery gels: analyzing deployment kinetics due to squeezing.
pubmed:affiliation
Department of Mechanical Engineering, University of Kansas, Lawrence, Kansas 66045, USA. kieweg@ku.edu
pubmed:publicationType
Journal Article, Research Support, N.I.H., Extramural