Linked Life Data

17093129

Source:http://linkedlifedata.com/resource/pubmed/id/17093129

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2007-3-13
pubmed:abstractText
Animals return to rewarded locations. An example of this is conditioned place preference (CPP), which is widely used in studies of drug reward. Although CPP is expressed as increased time spent in a previously rewarded location, the behavioral strategy underlying this change is unknown. We continuously monitored rats (n = 22) in a three-room in-line configuration, before and after morphine conditioning in one end room. Although sequential room visit durations were variable, their probability distribution was exponential, indicating that the processes controlling visit durations can be modeled by instantaneous room exit probabilities. Further analysis of room transitions and computer simulations of probabilistic models revealed that the exploratory bias toward the morphine room is best explained by an increase in the probability of a subset of rapid, direct transitions from the saline- to the morphine-paired room by the central room. This finding sharply delineates and constrains possible neural mechanisms for a class of self-initiated, goal-directed behaviors toward previously rewarded locations.
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0022-3077
pubmed:author
pubmed:issnType
Print
pubmed:volume
97
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2083-93
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
How prior reward experience biases exploratory movements: a probabilistic model.
pubmed:affiliation
Neuroscience Graduate Program, Department of Neurologyiology, University of California, San Francisco, California, USA. german@phy.ucsf.edu
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, Non-P.H.S., Research Support, Non-U.S. Gov't