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rdf:type |
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lifeskim:mentions |
umls-concept:C0007452,
umls-concept:C0007634,
umls-concept:C0015127,
umls-concept:C0021467,
umls-concept:C0021469,
umls-concept:C0205039,
umls-concept:C0257694,
umls-concept:C0541879,
umls-concept:C0595950,
umls-concept:C1182794,
umls-concept:C1314792
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pubmed:issue |
8
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pubmed:dateCreated |
2006-11-8
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pubmed:abstractText |
This study defines the in vitro phenomenon of ciliated bovine bronchial epithelial cell (BBEC) detachment from the basal epithelium and regulation of cilia motility mediated through protein kinase C epsilon (PKCepsilon). The authors determined the time course of activation and downregulation of PKCepsilon by the known PKC activator phorbol 12-myristate 13-acetate (PMA) and demonstrate that chemical inhibition of PKC by calphostin C or the novel PKC isoform inhibitor Ro 31-8220 induced striking detachment of ciliated BBECs from the basal cell monolayer within 1 hour, independent of apoptosis or necrotic cell death. The results of this study support a possible novel PKCepsilon-mediated signaling pathway through which ciliated cell attachment is maintained.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/17090476-10330401,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17090476-10526339,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17090476-10998203,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17090476-11134082,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17090476-11160332,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17090476-11696589,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17090476-11934885,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17090476-12370278,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17090476-12473185,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17090476-12867362,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17090476-12887704,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17090476-12937157,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17090476-14532285,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17090476-14654063,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17090476-14980256,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17090476-15357883,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17090476-15381733,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17090476-15784626,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17090476-8111584,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17090476-8340406,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17090476-8662811,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17090476-9360998,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17090476-9374728,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17090476-9688598,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17090476-9794251
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0190-2148
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
32
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
349-62
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pubmed:dateRevised |
2011-9-26
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pubmed:meshHeading |
pubmed-meshheading:17090476-Animals,
pubmed-meshheading:17090476-Bronchi,
pubmed-meshheading:17090476-Carcinogens,
pubmed-meshheading:17090476-Cattle,
pubmed-meshheading:17090476-Cell Adhesion,
pubmed-meshheading:17090476-Cells, Cultured,
pubmed-meshheading:17090476-Cilia,
pubmed-meshheading:17090476-Enzyme Activation,
pubmed-meshheading:17090476-Enzyme Inhibitors,
pubmed-meshheading:17090476-Indoles,
pubmed-meshheading:17090476-Naphthalenes,
pubmed-meshheading:17090476-Protein Kinase C-epsilon,
pubmed-meshheading:17090476-Respiratory Mucosa,
pubmed-meshheading:17090476-Signal Transduction,
pubmed-meshheading:17090476-Tetradecanoylphorbol Acetate
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pubmed:year |
2006
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pubmed:articleTitle |
Inhibition of protein kinase C epsilon causes ciliated bovine bronchial cell detachment.
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pubmed:affiliation |
Pulmonary, Critical Care and Sleep Medicine Section, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, Nebraska 68198-5300, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, N.I.H., Extramural
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