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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5006
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pubmed:dateCreated |
1991-5-31
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pubmed:abstractText |
Src homology (SH) regions 2 and 3 are noncatalytic domains that are conserved among a series of cytoplasmic signaling proteins regulated by receptor protein-tyrosine kinases, including phospholipase C-gamma, Ras GTPase (guanosine triphosphatase)-activating protein, and Src-like tyrosine kinases. The SH2 domains of these signaling proteins bind tyrosine phosphorylated polypeptides, implicated in normal signaling and cellular transformation. Tyrosine phosphorylation acts as a switch to induce the binding of SH2 domains, thereby mediating the formation of heteromeric protein complexes at or near the plasma membrane. The formation of these complexes is likely to control the activation of signal transduction pathways by tyrosine kinases. The SH3 domain is a distinct motif that, together with SH2, may modulate interactions with the cytoskeleton and membrane. Some signaling and transforming proteins contain SH2 and SH3 domains unattached to any known catalytic element. These noncatalytic proteins may serve as adaptors to link tyrosine kinases to specific target proteins. These observations suggest that SH2 and SH3 domains participate in the control of intracellular responses to growth factor stimulation.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Epidermal Growth Factor,
http://linkedlifedata.com/resource/pubmed/chemical/GTPase-Activating Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphotyrosine,
http://linkedlifedata.com/resource/pubmed/chemical/Platelet-Derived Growth Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Sorting Signals,
http://linkedlifedata.com/resource/pubmed/chemical/Protein-Tyrosine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, Epidermal Growth Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Cell Surface,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Platelet-Derived Growth...,
http://linkedlifedata.com/resource/pubmed/chemical/Type C Phospholipases,
http://linkedlifedata.com/resource/pubmed/chemical/Tyrosine,
http://linkedlifedata.com/resource/pubmed/chemical/ras GTPase-Activating Proteins
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0036-8075
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
3
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pubmed:volume |
252
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
668-74
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:1708916-Amino Acid Sequence,
pubmed-meshheading:1708916-Binding Sites,
pubmed-meshheading:1708916-Cytoplasm,
pubmed-meshheading:1708916-Epidermal Growth Factor,
pubmed-meshheading:1708916-GTPase-Activating Proteins,
pubmed-meshheading:1708916-Molecular Sequence Data,
pubmed-meshheading:1708916-Phosphoproteins,
pubmed-meshheading:1708916-Phosphorylation,
pubmed-meshheading:1708916-Phosphotyrosine,
pubmed-meshheading:1708916-Platelet-Derived Growth Factor,
pubmed-meshheading:1708916-Protein Sorting Signals,
pubmed-meshheading:1708916-Protein-Tyrosine Kinases,
pubmed-meshheading:1708916-Proteins,
pubmed-meshheading:1708916-Receptor, Epidermal Growth Factor,
pubmed-meshheading:1708916-Receptors, Cell Surface,
pubmed-meshheading:1708916-Receptors, Platelet-Derived Growth Factor,
pubmed-meshheading:1708916-Sequence Homology, Nucleic Acid,
pubmed-meshheading:1708916-Signal Transduction,
pubmed-meshheading:1708916-Type C Phospholipases,
pubmed-meshheading:1708916-Tyrosine,
pubmed-meshheading:1708916-ras GTPase-Activating Proteins
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pubmed:year |
1991
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pubmed:articleTitle |
SH2 and SH3 domains: elements that control interactions of cytoplasmic signaling proteins.
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pubmed:affiliation |
Division of Molecular and Developmental Biology, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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