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rdf:type |
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lifeskim:mentions |
umls-concept:C0003308,
umls-concept:C0027947,
umls-concept:C0087111,
umls-concept:C0153252,
umls-concept:C0205421,
umls-concept:C0871261,
umls-concept:C1280500,
umls-concept:C1517004,
umls-concept:C1704632,
umls-concept:C1706817,
umls-concept:C2911692
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pubmed:issue |
1
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pubmed:dateCreated |
2006-12-21
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pubmed:abstractText |
Disseminated candidiasis is associated with a high rate of morbidity and mortality. The presence of neutrophils and the timely administration of antifungal agents are likely to be critical factors for a favorable therapeutic outcome of this syndrome. The effect of neutropenia on the temporal profile of the burden of Candida albicans in untreated mice and those treated with amphotericin B was determined using a pharmacodynamic model of disseminated candidiasis. A mathematical model was developed to describe the rate and extent of the C. albicans killing attributable to neutrophils and to amphotericin B. The consequences of a delay in the administration of amphotericin B, flucytosine, or micafungin were studied by defining dose-response relationships. Neutrophils caused a logarithmic decline in fungal burden in treated and untreated mice. The combination of amphotericin B and neutrophils resulted in a high rate of Candida killing and a sustained anti-C. albicans effect. In neutropenic mice, 5 mg/kg of body weight of amphotericin B was required to prevent progressive logarithmic growth. An increased delay in drug administration resulted in a reduction in the maximum effect to a point at which no drug effect could be observed. Neutrophils and the timely initiation of antifungal agents are critical determinants in the treatment of experimental disseminated candidiasis.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/17088486-10828009,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17088486-11014620,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17088486-11360213,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17088486-11745210,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17088486-11825053,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17088486-11957023,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17088486-12654644,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17088486-1380052,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17088486-14557960,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17088486-15306996,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17088486-15529309,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17088486-15561880,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17088486-15813733,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17088486-15857941,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17088486-16028137,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17088486-16127033,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17088486-16304173,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17088486-16421795,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17088486-16954320,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17088486-2138654,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17088486-2184509,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17088486-3196127,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17088486-5216294,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17088486-7536791,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17088486-9037636,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17088486-9552086,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17088486-9593135,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17088486-9845853
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0066-4804
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
51
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
285-95
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:17088486-Amphotericin B,
pubmed-meshheading:17088486-Animals,
pubmed-meshheading:17088486-Antifungal Agents,
pubmed-meshheading:17088486-Candida albicans,
pubmed-meshheading:17088486-Candidiasis,
pubmed-meshheading:17088486-Disease Models, Animal,
pubmed-meshheading:17088486-Dose-Response Relationship, Drug,
pubmed-meshheading:17088486-Echinocandins,
pubmed-meshheading:17088486-Flucytosine,
pubmed-meshheading:17088486-Kidney,
pubmed-meshheading:17088486-Lipopeptides,
pubmed-meshheading:17088486-Lipoproteins,
pubmed-meshheading:17088486-Male,
pubmed-meshheading:17088486-Mice,
pubmed-meshheading:17088486-Microbial Sensitivity Tests,
pubmed-meshheading:17088486-Neutropenia,
pubmed-meshheading:17088486-Neutrophils,
pubmed-meshheading:17088486-Peptides, Cyclic,
pubmed-meshheading:17088486-Time Factors
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pubmed:year |
2007
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pubmed:articleTitle |
Effect of neutropenia and treatment delay on the response to antifungal agents in experimental disseminated candidiasis.
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pubmed:affiliation |
Pediatric Oncology Branch, NCI/NIH, CRC Room 1-5750, 10 Center Dr., MSC 1100, Bethesda, MD 20892-1100, USA. hopew@mail.nih.gov
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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