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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
21
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pubmed:dateCreated |
2006-11-22
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pubmed:abstractText |
Although numerous signaling pathways are known to be activated in experimental cardiac hypertrophy, the molecular basis of the hypertrophic response inherent in human heart diseases remains largely unknown. Integrin-linked kinase (ILK) is a multifunctional protein kinase that physically links beta-integrins with the actin cytoskeleton, suggesting a potential mechanoreceptor role.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
1524-4539
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pubmed:author |
pubmed-author:ColesJohn GJG,
pubmed-author:DaiXiaojingX,
pubmed-author:DuChangqingC,
pubmed-author:FedakPaul W MPW,
pubmed-author:HanniganGregoryG,
pubmed-author:HenkelmanMarkM,
pubmed-author:HinekAleksanderA,
pubmed-author:HusainMansoorM,
pubmed-author:LauArthurA,
pubmed-author:LuHuanzhangH,
pubmed-author:MongrooPerry SPS,
pubmed-author:YamabiHideakiH,
pubmed-author:ZhouYu-QingYQ
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pubmed:issnType |
Electronic
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pubmed:day |
21
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pubmed:volume |
114
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2271-9
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:17088456-Alanine,
pubmed-meshheading:17088456-Angiotensin II,
pubmed-meshheading:17088456-Animals,
pubmed-meshheading:17088456-Arginine,
pubmed-meshheading:17088456-Cardiomegaly,
pubmed-meshheading:17088456-Enzyme Activation,
pubmed-meshheading:17088456-Extracellular Signal-Regulated MAP Kinases,
pubmed-meshheading:17088456-Fetus,
pubmed-meshheading:17088456-Heart Ventricles,
pubmed-meshheading:17088456-Humans,
pubmed-meshheading:17088456-Infant,
pubmed-meshheading:17088456-Mice,
pubmed-meshheading:17088456-Mice, Transgenic,
pubmed-meshheading:17088456-Mutation,
pubmed-meshheading:17088456-Myocardium,
pubmed-meshheading:17088456-Myocytes, Cardiac,
pubmed-meshheading:17088456-Phosphorylation,
pubmed-meshheading:17088456-Protein-Serine-Threonine Kinases,
pubmed-meshheading:17088456-Ribosomal Protein S6 Kinases, 70-kDa,
pubmed-meshheading:17088456-Ventricular Outflow Obstruction,
pubmed-meshheading:17088456-cdc42 GTP-Binding Protein,
pubmed-meshheading:17088456-rac1 GTP-Binding Protein
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pubmed:year |
2006
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pubmed:articleTitle |
Integrin-linked kinase expression is elevated in human cardiac hypertrophy and induces hypertrophy in transgenic mice.
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pubmed:affiliation |
Cancer Research Program, Research Institute, Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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