Linked Life Data

1708834

Source:http://linkedlifedata.com/resource/pubmed/id/1708834

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
10
pubmed:dateCreated
1991-6-6
pubmed:abstractText
A neoangiogenic response is critical for the unrestricted growth of solid tumors beyond a few millimeters in diameter. Release of adequate growth-stimulating activity from tumor cells is obviously required for the stimulation of blood vessel growth, and blockade of such stimulatory activity should repress tumor growth at the microscopic level. To test this hypothesis and to study appropriate inhibitors, we used a human adrenal cancer cell line (SW-13/K-fgf) engineered to secrete Kaposi's sarcoma-derived fibroblast growth factor (K-FGF), which we previously showed to induce growth of highly vascularized subcutaneous tumors in animals by autocrine and paracrine stimuli. In the present study, we tested different polysulfates for their selective inhibition of proliferation induced by K-FGF versus proliferation independent of K-FGF. Suramin and dextran sulfate showed slight selective inhibition of K-FGF-induced proliferation, ie, inhibition three- and five-fold greater, respectively, than the inhibition of proliferation independent of K-FGF. In contrast, heparin was inactive. The heparin analogue pentosan polysulfate (PPS), however, showed selective inhibition that was more than 2000-fold greater. The inhibitory effects of PPS on growth of SW-13/K-fgf cells, as well as endothelial cells, were fully reversible by an excess of added FGF. Daily intraperitoneal injections of PPS were tolerated well by athymic nude mice and prevented growth of subcutaneous SW-13/K-fgf tumor xenografts. PPS will be a useful tool to elucidate the effects of FGFs in vitro and in vivo and appears to be a prototype for the development of tumoricidal therapy based on targeting of growth factors.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0027-8874
pubmed:author
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
83
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
716-20
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed-meshheading:1708834-Adrenal Gland Neoplasms, pubmed-meshheading:1708834-Animals, pubmed-meshheading:1708834-Breast Neoplasms, pubmed-meshheading:1708834-Cell Division, pubmed-meshheading:1708834-Endothelium, Vascular, pubmed-meshheading:1708834-Female, pubmed-meshheading:1708834-Fibroblast Growth Factor 4, pubmed-meshheading:1708834-Fibroblast Growth Factors, pubmed-meshheading:1708834-Heparin, pubmed-meshheading:1708834-Humans, pubmed-meshheading:1708834-Mice, pubmed-meshheading:1708834-Mice, Nude, pubmed-meshheading:1708834-Neoplasm Transplantation, pubmed-meshheading:1708834-Neovascularization, Pathologic, pubmed-meshheading:1708834-Pentosan Sulfuric Polyester, pubmed-meshheading:1708834-Proto-Oncogene Proteins, pubmed-meshheading:1708834-Suramin, pubmed-meshheading:1708834-Transfection, pubmed-meshheading:1708834-Tumor Cells, Cultured
pubmed:year
1991
pubmed:articleTitle
Tumor growth dependent on Kaposi's sarcoma-derived fibroblast growth factor inhibited by pentosan polysulfate.
pubmed:affiliation
Vincent T. Lombardi Cancer Research Center, Georgetown University Medical Center, Washington, DC 20007.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't