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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2006-11-7
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pubmed:abstractText |
Glucocorticoids are the mainstay of asthma therapy; however, a proportion of patients with asthma has a severe form of the disease that fails to respond to therapy. Understanding the molecular mechanisms behind glucocorticoid-insensitive asthma is therefore of clinical importance. Evidence in glucocorticoid-unresponsive Henrietta Lack (HeLa) cells indicated that cofilin-1 could act as an inhibitor of glucocorticoid function.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0091-6749
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
118
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1090-6
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pubmed:meshHeading |
pubmed-meshheading:17088134-Adult,
pubmed-meshheading:17088134-Asthma,
pubmed-meshheading:17088134-CD4-Positive T-Lymphocytes,
pubmed-meshheading:17088134-Cells, Cultured,
pubmed-meshheading:17088134-Cofilin 1,
pubmed-meshheading:17088134-Cytokines,
pubmed-meshheading:17088134-Dexamethasone,
pubmed-meshheading:17088134-Female,
pubmed-meshheading:17088134-Forced Expiratory Volume,
pubmed-meshheading:17088134-Glucocorticoids,
pubmed-meshheading:17088134-Humans,
pubmed-meshheading:17088134-Immunosuppressive Agents,
pubmed-meshheading:17088134-Jurkat Cells,
pubmed-meshheading:17088134-Male,
pubmed-meshheading:17088134-Middle Aged,
pubmed-meshheading:17088134-Severity of Illness Index
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pubmed:year |
2006
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pubmed:articleTitle |
Expression of nonmuscle cofilin-1 and steroid responsiveness in severe asthma.
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pubmed:affiliation |
Airways Disease Section, National Heart and Lung Institute, Imperial College London, London, UK.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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