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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2006-12-15
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pubmed:abstractText |
A new series of arylalkyl- and alkenylamines was designed, synthesized, and evaluated for binding to sigma(1) and sigma(2) receptors. Many compounds exhibited nanomolar affinity for sigma(1) subtype receptor with good selectivity over sigma(2). A molecular modeling study was conducted in order to rationalize the experimental data, and the structure-receptor affinities are discussed.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0968-0896
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pubmed:author |
pubmed-author:AlcaroStefanoS,
pubmed-author:AzzolinaOrnellaO,
pubmed-author:CallegariAthosA,
pubmed-author:CollinaSimonaS,
pubmed-author:LaggnerChristianC,
pubmed-author:LangerThierryT,
pubmed-author:LinatiLauraL,
pubmed-author:LoddoGuyaG,
pubmed-author:OrtusoFrancescoF,
pubmed-author:PrezzaventoOrazioO,
pubmed-author:RonsisvalleGiuseppeG,
pubmed-author:UrbanoMariangelaM
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
15
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
771-83
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:17088069-Animals,
pubmed-meshheading:17088069-Brain,
pubmed-meshheading:17088069-Chemistry, Physical,
pubmed-meshheading:17088069-Chromatography, Thin Layer,
pubmed-meshheading:17088069-Drug Design,
pubmed-meshheading:17088069-Guinea Pigs,
pubmed-meshheading:17088069-Indicators and Reagents,
pubmed-meshheading:17088069-Magnetic Resonance Spectroscopy,
pubmed-meshheading:17088069-Membranes,
pubmed-meshheading:17088069-Models, Molecular,
pubmed-meshheading:17088069-Molecular Conformation,
pubmed-meshheading:17088069-Physicochemical Phenomena,
pubmed-meshheading:17088069-Radioligand Assay,
pubmed-meshheading:17088069-Receptors, sigma,
pubmed-meshheading:17088069-Structure-Activity Relationship
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pubmed:year |
2007
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pubmed:articleTitle |
Design, synthesis, and SAR analysis of novel selective sigma1 ligands.
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pubmed:affiliation |
Dipartimento di Chimica Farmaceutica, Università di Pavia, Viale Taramelli 12, 27100 Pavia, Italy. simona.collina@unipv.it
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pubmed:publicationType |
Journal Article,
In Vitro
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