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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2007-1-18
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pubmed:abstractText |
OPN is an ECM protein with diverse localization and functionality. The role of OPN during fracture healing was examined using wildtype and OPN(-/-) mice. Results showed that OPN plays an important role in regulation of angiogenesis, callus formation, and mechanical strength in early stages of healing and facilitates late stage bone remodeling and ECM organization.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0884-0431
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
22
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
286-97
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pubmed:dateRevised |
2007-12-3
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pubmed:meshHeading |
pubmed-meshheading:17087627-Animals,
pubmed-meshheading:17087627-Base Sequence,
pubmed-meshheading:17087627-Biomechanics,
pubmed-meshheading:17087627-DNA Primers,
pubmed-meshheading:17087627-Fracture Healing,
pubmed-meshheading:17087627-Male,
pubmed-meshheading:17087627-Mice,
pubmed-meshheading:17087627-Mice, Inbred C57BL,
pubmed-meshheading:17087627-Mice, Knockout,
pubmed-meshheading:17087627-Neovascularization, Physiologic,
pubmed-meshheading:17087627-Osteopontin,
pubmed-meshheading:17087627-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:17087627-Tomography, X-Ray Computed
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pubmed:year |
2007
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pubmed:articleTitle |
Impaired angiogenesis, early callus formation, and late stage remodeling in fracture healing of osteopontin-deficient mice.
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pubmed:affiliation |
Wallace H Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, Georgia, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, N.I.H., Extramural
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