Linked Life Data

17087607

Source:http://linkedlifedata.com/resource/pubmed/id/17087607

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2008-1-16
pubmed:abstractText
The LRP5 gene is believed to be primarily associated with bone metabolism via Wnt signaling. The latter pathway, however, appears to control various other systems outside the skeleton. To find the relationships of the LRP5 gene to serum follicle stimulating hormone (FSH) and luteinizing hormone (LH) in the cohort of normal postmenopausal women, we identified the C/T (c.4037:A1330V) polymorphism in the LRP5 gene using a restriction analysis of the PCR product in a cohort of 165 untreated pre- and post-menopausal women. In a subset of 111 post-menopausal women we analyzed the association between the LRP5 genotype and serum levels of sex-hormones including FSH and LH. The distribution of CC, TC and TT genotypes of the C/T polymorphism in the whole group was 73.9 %, 23.6 % and 2.4 %, respectively, which is comparable with other Caucasian populations. As no TT homozygote was found in the group of post-menopausal women, serum sex-hormones were compared between CC and TC genotypes. Women with the CT allele combination had markedly higher serum FSH levels as compared to carriers of the CC genotype (p<0.004). No differences between these genotypes were found in serum LH levels as well as the circulating sex-steroids such as estradiol, testosterone, dehydroepiandrosterone and/or its sulphate, androstenedione and SHBG. To conclude, the LRP5 gene is associated with circulating FSH in normal post-menopausal women in the present study. The mediating role of subtle undetectable variations in estrogen levels is discussed. We did not find any relationship between the LRP-5 genotype and serum LH levels.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0862-8408
pubmed:author
pubmed:issnType
Print
pubmed:volume
56
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
735-9
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed-meshheading:17087607-Aged, pubmed-meshheading:17087607-Androstenedione, pubmed-meshheading:17087607-Bone and Bones, pubmed-meshheading:17087607-Czech Republic, pubmed-meshheading:17087607-Dehydroepiandrosterone, pubmed-meshheading:17087607-Dehydroepiandrosterone Sulfate, pubmed-meshheading:17087607-European Continental Ancestry Group, pubmed-meshheading:17087607-Female, pubmed-meshheading:17087607-Follicle Stimulating Hormone, pubmed-meshheading:17087607-Gene Frequency, pubmed-meshheading:17087607-Genotype, pubmed-meshheading:17087607-Humans, pubmed-meshheading:17087607-LDL-Receptor Related Proteins, pubmed-meshheading:17087607-Low Density Lipoprotein Receptor-Related Protein-5, pubmed-meshheading:17087607-Luteinizing Hormone, pubmed-meshheading:17087607-Middle Aged, pubmed-meshheading:17087607-Polymorphism, Genetic, pubmed-meshheading:17087607-Postmenopause, pubmed-meshheading:17087607-Reverse Transcriptase Polymerase Chain Reaction, pubmed-meshheading:17087607-Sex Hormone-Binding Globulin
pubmed:year
2007
pubmed:articleTitle
Association of C/T polymorphism in the LRP5 gene with circulating follicle stimulating hormone in Caucasian postmenopausal women.
pubmed:affiliation
Institute of Endocrinology, Prague, Czech Republic. izofko@endo.cz
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't