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PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2006-11-7
pubmed:abstractText
The aim of this study was to determine whether there was an association between body fat distribution, blood lipid profiles, and beta 3-adrenergic receptor gene polymorphism in Korean middle-aged women. Subjects were grouped according to BMI as obese (> or = 5 BMI, n = 95) or non-obese (BMI<25, n = 93). The Trp64Arg mutation of the beta 3-adrenergic receptor gene was detected by PCR-RFLP. Skinfold thickness, body circumference, intra-abdominal fat area by CT, and blood lipid profiles were also measured. Data were compared using ANOVA, Bonferroni t-test, and Chi-square. Significance for statistical analyses were set at p<0.05. In the obese group, 63.16% were Trp64Trp homozygotes and 36.84% were Trp64Arg heterozygotes, compared to 80.65% who were Trp64Trp homozygotes and 19.35% who were Trp64Arg heterozygotes in the non-obese group. These results indicated a significant (chi-square = 4.943, p<0.05) difference between the two groups. Frequency of the Arg64 allele in the obese group (16.84%) showed a significant (chi-square = 4.185, p<0.05) difference as compared to the non-obese group (9.68%). Skinfold thickness and body circumference of the Trp64Arg heterozygote group showed a consistent increase as compared to the Trp64Trp homozygote group. Visceral fat area and VSR of Trp64Arg heterozygote group showed a higher tendency than Trp64Trp homozygotes in the obese group, but these differences were not statistically significant. In conclusion, the Trp64Arg polymorphism of the beta 3-adrenergic receptor gene is associated with obesity in middle-aged Korean women, but it is difficult to suggest the prominent association of the Trp64Arg polymorphism of the beta 3-adrenergic receptor gene with prevalence of abdominal obesity or dyslipidemia in Korean middle-aged women.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0301-4800
pubmed:author
pubmed:issnType
Print
pubmed:volume
52
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
281-6
pubmed:meshHeading
pubmed-meshheading:17087055-Arginine, pubmed-meshheading:17087055-Blood Glucose, pubmed-meshheading:17087055-Body Fat Distribution, pubmed-meshheading:17087055-Body Mass Index, pubmed-meshheading:17087055-Cholesterol, HDL, pubmed-meshheading:17087055-Fatty Acids, Nonesterified, pubmed-meshheading:17087055-Female, pubmed-meshheading:17087055-Heterozygote, pubmed-meshheading:17087055-Homozygote, pubmed-meshheading:17087055-Humans, pubmed-meshheading:17087055-Hyperlipidemias, pubmed-meshheading:17087055-Korea, pubmed-meshheading:17087055-Lipids, pubmed-meshheading:17087055-Middle Aged, pubmed-meshheading:17087055-Mutation, pubmed-meshheading:17087055-Obesity, pubmed-meshheading:17087055-Polymerase Chain Reaction, pubmed-meshheading:17087055-Polymorphism, Restriction Fragment Length, pubmed-meshheading:17087055-Receptors, Adrenergic, beta-3, pubmed-meshheading:17087055-Skinfold Thickness, pubmed-meshheading:17087055-Triglycerides, pubmed-meshheading:17087055-Tryptophan
pubmed:year
2006
pubmed:articleTitle
Comparison of body fat distribution and blood lipid profiles according to Trp64Arg polymorphism for the beta 3-adrenergic receptor gene in Korean middle-aged women.
pubmed:affiliation
Department of Physical Education, Keimyung University, 1000, Shindang-dong, Dalseo-gu, Daegu, 704-701, Korea. kjk744@kmu.ac.kr
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't