Source:http://linkedlifedata.com/resource/pubmed/id/17087055
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
4
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pubmed:dateCreated |
2006-11-7
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pubmed:abstractText |
The aim of this study was to determine whether there was an association between body fat distribution, blood lipid profiles, and beta 3-adrenergic receptor gene polymorphism in Korean middle-aged women. Subjects were grouped according to BMI as obese (> or = 5 BMI, n = 95) or non-obese (BMI<25, n = 93). The Trp64Arg mutation of the beta 3-adrenergic receptor gene was detected by PCR-RFLP. Skinfold thickness, body circumference, intra-abdominal fat area by CT, and blood lipid profiles were also measured. Data were compared using ANOVA, Bonferroni t-test, and Chi-square. Significance for statistical analyses were set at p<0.05. In the obese group, 63.16% were Trp64Trp homozygotes and 36.84% were Trp64Arg heterozygotes, compared to 80.65% who were Trp64Trp homozygotes and 19.35% who were Trp64Arg heterozygotes in the non-obese group. These results indicated a significant (chi-square = 4.943, p<0.05) difference between the two groups. Frequency of the Arg64 allele in the obese group (16.84%) showed a significant (chi-square = 4.185, p<0.05) difference as compared to the non-obese group (9.68%). Skinfold thickness and body circumference of the Trp64Arg heterozygote group showed a consistent increase as compared to the Trp64Trp homozygote group. Visceral fat area and VSR of Trp64Arg heterozygote group showed a higher tendency than Trp64Trp homozygotes in the obese group, but these differences were not statistically significant. In conclusion, the Trp64Arg polymorphism of the beta 3-adrenergic receptor gene is associated with obesity in middle-aged Korean women, but it is difficult to suggest the prominent association of the Trp64Arg polymorphism of the beta 3-adrenergic receptor gene with prevalence of abdominal obesity or dyslipidemia in Korean middle-aged women.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Arginine,
http://linkedlifedata.com/resource/pubmed/chemical/Blood Glucose,
http://linkedlifedata.com/resource/pubmed/chemical/Cholesterol, HDL,
http://linkedlifedata.com/resource/pubmed/chemical/Fatty Acids, Nonesterified,
http://linkedlifedata.com/resource/pubmed/chemical/Lipids,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Adrenergic, beta-3,
http://linkedlifedata.com/resource/pubmed/chemical/Triglycerides,
http://linkedlifedata.com/resource/pubmed/chemical/Tryptophan
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0301-4800
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
52
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
281-6
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pubmed:meshHeading |
pubmed-meshheading:17087055-Arginine,
pubmed-meshheading:17087055-Blood Glucose,
pubmed-meshheading:17087055-Body Fat Distribution,
pubmed-meshheading:17087055-Body Mass Index,
pubmed-meshheading:17087055-Cholesterol, HDL,
pubmed-meshheading:17087055-Fatty Acids, Nonesterified,
pubmed-meshheading:17087055-Female,
pubmed-meshheading:17087055-Heterozygote,
pubmed-meshheading:17087055-Homozygote,
pubmed-meshheading:17087055-Humans,
pubmed-meshheading:17087055-Hyperlipidemias,
pubmed-meshheading:17087055-Korea,
pubmed-meshheading:17087055-Lipids,
pubmed-meshheading:17087055-Middle Aged,
pubmed-meshheading:17087055-Mutation,
pubmed-meshheading:17087055-Obesity,
pubmed-meshheading:17087055-Polymerase Chain Reaction,
pubmed-meshheading:17087055-Polymorphism, Restriction Fragment Length,
pubmed-meshheading:17087055-Receptors, Adrenergic, beta-3,
pubmed-meshheading:17087055-Skinfold Thickness,
pubmed-meshheading:17087055-Triglycerides,
pubmed-meshheading:17087055-Tryptophan
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pubmed:year |
2006
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pubmed:articleTitle |
Comparison of body fat distribution and blood lipid profiles according to Trp64Arg polymorphism for the beta 3-adrenergic receptor gene in Korean middle-aged women.
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pubmed:affiliation |
Department of Physical Education, Keimyung University, 1000, Shindang-dong, Dalseo-gu, Daegu, 704-701, Korea. kjk744@kmu.ac.kr
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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