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rdf:type |
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lifeskim:mentions |
umls-concept:C0017262,
umls-concept:C0020538,
umls-concept:C0035094,
umls-concept:C0205263,
umls-concept:C0314603,
umls-concept:C0439793,
umls-concept:C0441800,
umls-concept:C0441889,
umls-concept:C0521213,
umls-concept:C0702240,
umls-concept:C2350483
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pubmed:issue |
2
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pubmed:dateCreated |
2006-11-3
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pubmed:abstractText |
Transgenic rats with inducible angiotensin II (Ang II)-dependent hypertension (strain name: TGR[Cyp1a1-Ren2]) were generated by inserting the mouse Ren2 renin gene, fused to the cytochrome P450 1a1 (Cyp1a1) promoter, into the genome of the rat. The present study was performed to characterise the changes in plasma and kidney tissue Ang II levels and in renal haemodynamic function in Cyp1a1-Ren2 rats following induction of either slowly developing or malignant hypertension in these transgenic rats.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
1470-3203
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
7
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
74-86
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:17083061-Angiotensin II,
pubmed-meshheading:17083061-Angiotensin II Type 1 Receptor Blockers,
pubmed-meshheading:17083061-Animals,
pubmed-meshheading:17083061-Animals, Genetically Modified,
pubmed-meshheading:17083061-Gene Expression,
pubmed-meshheading:17083061-Hypertension,
pubmed-meshheading:17083061-Hypertension, Malignant,
pubmed-meshheading:17083061-Indoles,
pubmed-meshheading:17083061-Kidney,
pubmed-meshheading:17083061-Male,
pubmed-meshheading:17083061-Mice,
pubmed-meshheading:17083061-Promoter Regions, Genetic,
pubmed-meshheading:17083061-Rats,
pubmed-meshheading:17083061-Receptor, Angiotensin, Type 1,
pubmed-meshheading:17083061-Renin,
pubmed-meshheading:17083061-Renin-Angiotensin System
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pubmed:year |
2006
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pubmed:articleTitle |
Genetic clamping of renin gene expression induces hypertension and elevation of intrarenal Ang II levels of graded severity in Cyp1a1-Ren2 transgenic rats.
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pubmed:affiliation |
Department of Physiology, Tulane University Health Sciences Center, New Orleans, Louisiana, USA. kdmitch@tulane.edu
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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