| pubmed-article:17083039 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17083039 | lifeskim:mentions | umls-concept:C0019704 | lld:lifeskim |
| pubmed-article:17083039 | lifeskim:mentions | umls-concept:C0021311 | lld:lifeskim |
| pubmed-article:17083039 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:17083039 | lifeskim:mentions | umls-concept:C0040300 | lld:lifeskim |
| pubmed-article:17083039 | lifeskim:mentions | umls-concept:C0020731 | lld:lifeskim |
| pubmed-article:17083039 | lifeskim:mentions | umls-concept:C0205064 | lld:lifeskim |
| pubmed-article:17083039 | lifeskim:mentions | umls-concept:C0024432 | lld:lifeskim |
| pubmed-article:17083039 | lifeskim:mentions | umls-concept:C1367477 | lld:lifeskim |
| pubmed-article:17083039 | lifeskim:mentions | umls-concept:C1167622 | lld:lifeskim |
| pubmed-article:17083039 | lifeskim:mentions | umls-concept:C1704259 | lld:lifeskim |
| pubmed-article:17083039 | lifeskim:mentions | umls-concept:C0439148 | lld:lifeskim |
| pubmed-article:17083039 | lifeskim:mentions | umls-concept:C1705987 | lld:lifeskim |
| pubmed-article:17083039 | lifeskim:mentions | umls-concept:C1314939 | lld:lifeskim |
| pubmed-article:17083039 | pubmed:issue | 11 | lld:pubmed |
| pubmed-article:17083039 | pubmed:dateCreated | 2006-11-3 | lld:pubmed |
| pubmed-article:17083039 | pubmed:abstractText | Pertussis toxin (PTX) and its binding unit (PTX-B) have been shown to inhibit human immunodeficiency virus (HIV)-1 infection of primary cells. However, the anti-HIV mechanisms have yet to be defined. We demonstrate that PTX inhibits HIV-1 infection of human cervical tissue independently of viral tropism. PTX-B showed a similar pattern of HIV-1 inhibition. Further investigation in macrophages demonstrated that PTX/PTX-B inhibited HIV-1 expression but that other G protein inhibitors and activators had no effect on HIV-1 replication. Unlike the anti-HIV bacterial lipopolysaccharide, the anti-HIV effects of PTX/PTX-B were not due to beta -chemokine production or coreceptor down-modulation, but they were dependent on interaction with cell-surface receptors. Antibody blocking studies suggested that cell-surface CD14 is very likely to be the principal receptor involved in the anti-HIV effects of PTX/PTX-B. This was further strengthened by the results of surface plasmon resonance analyses. Further definition of the mechanisms of such inhibition may lead to the development of novel HIV-1 prevention strategies. | lld:pubmed |
| pubmed-article:17083039 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17083039 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17083039 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17083039 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:17083039 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:17083039 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17083039 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17083039 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:17083039 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17083039 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17083039 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:17083039 | pubmed:issn | 0022-1899 | lld:pubmed |
| pubmed-article:17083039 | pubmed:author | pubmed-author:GriffinGeorge... | lld:pubmed |
| pubmed-article:17083039 | pubmed:author | pubmed-author:ShattockRobin... | lld:pubmed |
| pubmed-article:17083039 | pubmed:author | pubmed-author:KellyCharlesC | lld:pubmed |
| pubmed-article:17083039 | pubmed:author | pubmed-author:HuQinxueQ | lld:pubmed |
| pubmed-article:17083039 | pubmed:author | pubmed-author:YounsonJustin... | lld:pubmed |
| pubmed-article:17083039 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17083039 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:17083039 | pubmed:volume | 194 | lld:pubmed |
| pubmed-article:17083039 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17083039 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17083039 | pubmed:pagination | 1547-56 | lld:pubmed |
| pubmed-article:17083039 | pubmed:dateRevised | 2007-12-3 | lld:pubmed |
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| pubmed-article:17083039 | pubmed:meshHeading | pubmed-meshheading:17083039... | lld:pubmed |
| pubmed-article:17083039 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:17083039 | pubmed:articleTitle | Pertussis toxin and its binding unit inhibit HIV-1 infection of human cervical tissue and macrophages involving a CD14 pathway. | lld:pubmed |
| pubmed-article:17083039 | pubmed:affiliation | Center for Infection, Department of Cellular and Molecular Medicine, St. George's University of London, London SW17 0RE, UK. | lld:pubmed |
| pubmed-article:17083039 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:17083039 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:17083039 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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