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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
11
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pubmed:dateCreated |
2006-11-3
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pubmed:abstractText |
Meningococcal disease occurs after colonization of the nasopharynx with Neisseria meningitidis. Surfactant protein (SP)-A and SP-D are pattern-recognition molecules of the respiratory tract that activate inflammatory and phagocytic defences after binding to microbial sugars. Variation in the genes of the surfactant proteins affects the expression and function of these molecules.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
1537-6591
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
1
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pubmed:volume |
43
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1426-33
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pubmed:meshHeading |
pubmed-meshheading:17083016-Adult,
pubmed-meshheading:17083016-Aged,
pubmed-meshheading:17083016-Alleles,
pubmed-meshheading:17083016-Amino Acid Substitution,
pubmed-meshheading:17083016-Binding Sites,
pubmed-meshheading:17083016-Case-Control Studies,
pubmed-meshheading:17083016-Child,
pubmed-meshheading:17083016-Child, Preschool,
pubmed-meshheading:17083016-Genetic Predisposition to Disease,
pubmed-meshheading:17083016-Haplotypes,
pubmed-meshheading:17083016-Humans,
pubmed-meshheading:17083016-Infant,
pubmed-meshheading:17083016-Infant, Newborn,
pubmed-meshheading:17083016-Meningococcal Infections,
pubmed-meshheading:17083016-Middle Aged,
pubmed-meshheading:17083016-Odds Ratio,
pubmed-meshheading:17083016-Polymorphism, Genetic,
pubmed-meshheading:17083016-Protein Structure, Tertiary,
pubmed-meshheading:17083016-Pulmonary Surfactant-Associated Protein A,
pubmed-meshheading:17083016-Pulmonary Surfactant-Associated Protein D
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pubmed:year |
2006
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pubmed:articleTitle |
Genetic polymorphism of the binding domain of surfactant protein-A2 increases susceptibility to meningococcal disease.
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pubmed:affiliation |
Academic Unit of Infection and Immunity, Division of Genomic Medicine, University of Sheffield, Sheffield, S10 2RX, United Kingdom. D.L.Jack@sheffield.ac.uk
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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