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rdf:type |
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lifeskim:mentions |
umls-concept:C0024432,
umls-concept:C0035820,
umls-concept:C0206131,
umls-concept:C0333348,
umls-concept:C0392747,
umls-concept:C0443172,
umls-concept:C0522534,
umls-concept:C0670896,
umls-concept:C1704259,
umls-concept:C1704675,
umls-concept:C1705987
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pubmed:issue |
1
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pubmed:dateCreated |
2006-12-22
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pubmed:abstractText |
Previous studies demonstrated that obese adipose tissue is characterized by increased infiltration of macrophages, suggesting that they might represent an important source of inflammation. Using an in vitro coculture system composed of 3T3-L1 adipocytes and RAW264 macrophages, we previously demonstrated that saturated fatty acids (FAs) and tumor necrosis factor (TNF)-alpha derived from adipocytes and macrophages, respectively, play a major role in the coculture-induced inflammatory changes.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
1524-4636
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pubmed:author |
pubmed-author:AoeSeiichiroS,
pubmed-author:ItohMichikoM,
pubmed-author:KameiYasutomiY,
pubmed-author:KotaniHidehitoH,
pubmed-author:MiyakeKensukeK,
pubmed-author:MizuaraiShinjiS,
pubmed-author:NishidaJunkoJ,
pubmed-author:OgawaYoshihiroY,
pubmed-author:SuganamiTakayoshiT,
pubmed-author:Tanimoto-KoyamaKanamiK,
pubmed-author:YamaokaShojiS,
pubmed-author:YuanXunmeiX
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pubmed:issnType |
Electronic
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pubmed:volume |
27
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
84-91
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pubmed:meshHeading |
pubmed-meshheading:17082484-Adipocytes,
pubmed-meshheading:17082484-Animals,
pubmed-meshheading:17082484-Cell Communication,
pubmed-meshheading:17082484-Cell Line,
pubmed-meshheading:17082484-Coculture Techniques,
pubmed-meshheading:17082484-Fatty Acids,
pubmed-meshheading:17082484-Fatty Acids, Nonesterified,
pubmed-meshheading:17082484-Gene Expression Regulation,
pubmed-meshheading:17082484-Hypertrophy,
pubmed-meshheading:17082484-Inflammation,
pubmed-meshheading:17082484-Lipolysis,
pubmed-meshheading:17082484-Macrophages,
pubmed-meshheading:17082484-Mice,
pubmed-meshheading:17082484-Mice, Mutant Strains,
pubmed-meshheading:17082484-NF-kappa B,
pubmed-meshheading:17082484-Obesity,
pubmed-meshheading:17082484-Signal Transduction,
pubmed-meshheading:17082484-Toll-Like Receptor 4,
pubmed-meshheading:17082484-Tumor Necrosis Factor-alpha
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pubmed:year |
2007
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pubmed:articleTitle |
Role of the Toll-like receptor 4/NF-kappaB pathway in saturated fatty acid-induced inflammatory changes in the interaction between adipocytes and macrophages.
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pubmed:affiliation |
Department of Molecular Medicine and Metabolism, Medical Research Institute, Tokyo Medical and Dental University, 2-3-10 Kanda-surugadai, Chiyoda-ku, Tokyo 101-0062, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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