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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2006-11-20
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pubmed:abstractText |
Solid-phase synthesis of a small combinatorial library of dihydroceramide analogues as mixtures of erythro and threo diastereomers is described. Some dihydroceramide analogues cause growth arrest and apoptosis in a dose-dependent manner in human alveolar epithelial cells. This activity is likely due to the threo isomers, as evidenced by cellular studies with a pair of diastereomerically pure N-acyldihydrosphingosines. The apoptotic activity reported in this work provides information for the design of new compounds that may provide the basis for the generation of biochemical tools for the study of different pathologies where ceramide and/or dihydroceramide are involved.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0968-0896
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pubmed:author |
pubmed-author:CanalsDanielD,
pubmed-author:CardeLydiaL,
pubmed-author:CasasJosefinaJ,
pubmed-author:DelgadoAntonioA,
pubmed-author:FabriàsGemmaG,
pubmed-author:GrijalvoSantiagoS,
pubmed-author:LlebariaAmadeuA,
pubmed-author:PascualRosaliaR,
pubmed-author:RabalObduliaO,
pubmed-author:TeixidóJordiJ,
pubmed-author:VillorbinaGemmaG
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
15
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
50-62
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pubmed:meshHeading |
pubmed-meshheading:17081760-Apoptosis,
pubmed-meshheading:17081760-Binding Sites,
pubmed-meshheading:17081760-Cell Cycle,
pubmed-meshheading:17081760-Cell Line,
pubmed-meshheading:17081760-Cell Proliferation,
pubmed-meshheading:17081760-Ceramides,
pubmed-meshheading:17081760-Combinatorial Chemistry Techniques,
pubmed-meshheading:17081760-Dose-Response Relationship, Drug,
pubmed-meshheading:17081760-Drug Design,
pubmed-meshheading:17081760-Drug Evaluation, Preclinical,
pubmed-meshheading:17081760-Epithelial Cells,
pubmed-meshheading:17081760-Flow Cytometry,
pubmed-meshheading:17081760-Humans,
pubmed-meshheading:17081760-Molecular Structure,
pubmed-meshheading:17081760-Pulmonary Alveoli,
pubmed-meshheading:17081760-Sensitivity and Specificity,
pubmed-meshheading:17081760-Stereoisomerism
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pubmed:year |
2007
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pubmed:articleTitle |
Solid-phase synthesis of a combinatorial library of dihydroceramide analogues and its activity in human alveolar epithelial cells.
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pubmed:affiliation |
Research Unit on BioActive Molecules (RUBAM), Departament de Química Orgànica Biològica, Institut d'Investigacions Químiques i Ambientals de Barcelona (IIQAB-C.S.I.C), Jordi Girona 18-26, 08034 Barcelona, Spain.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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