|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
8
|
|
pubmed:dateCreated |
2007-7-30
|
|
pubmed:abstractText |
The epidermal growth factor receptor (EGFR) has been reported to be overexpressed in anaplastic thyroid carcinoma (ATC). In vitro studies have shown that EGFR tyrosine kinase inhibitors (TKIs) greatly inhibit cellular growth and induced apoptosis in the ATC cell lines, while somatic mutations in the tyrosine kinase domain or an increased gene copy number are associated with increased sensitivity to TKIs in non-small cell lung cancer.
|
|
pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/17079354,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17079354-11742333,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17079354-12568441,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17079354-12748244,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17079354-12876205,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17079354-12953099,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17079354-14570950,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17079354-14744244,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17079354-15017643,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17079354-15099021,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17079354-15118073,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17079354-15118125,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17079354-15143334,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17079354-15163002,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17079354-15329413,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17079354-15623643,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17079354-15659782,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17079354-15785737,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17079354-15870435,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17079354-15920544,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17079354-15998906,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17079354-16014882,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17079354-16282176,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17079354-16739104
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
AIM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Aug
|
|
pubmed:issn |
0021-9746
|
|
pubmed:author |
pubmed-author:ChoBo YounBY,
pubmed-author:ChungKi-WookKW,
pubmed-author:KeamBhumsukB,
pubmed-author:KimSeok WonSW,
pubmed-author:KimSun WookSW,
pubmed-author:KongSun-YoungSY,
pubmed-author:KookMyoung ChulMC,
pubmed-author:LeeDae HoDH,
pubmed-author:LeeEun SookES,
pubmed-author:LeeGeon KookGK,
pubmed-author:ParkDo Joondo J,
pubmed-author:ParkSeong HoeSH,
pubmed-author:ParkSo YeonSY,
pubmed-author:YangSun KyungSK
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
60
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
881-4
|
|
pubmed:dateRevised |
2010-9-14
|
|
pubmed:meshHeading |
pubmed-meshheading:17079354-Aged,
pubmed-meshheading:17079354-Aged, 80 and over,
pubmed-meshheading:17079354-DNA, Neoplasm,
pubmed-meshheading:17079354-DNA Mutational Analysis,
pubmed-meshheading:17079354-Female,
pubmed-meshheading:17079354-Gene Amplification,
pubmed-meshheading:17079354-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:17079354-Genes, erbB-1,
pubmed-meshheading:17079354-Humans,
pubmed-meshheading:17079354-Immunohistochemistry,
pubmed-meshheading:17079354-In Situ Hybridization, Fluorescence,
pubmed-meshheading:17079354-Male,
pubmed-meshheading:17079354-Middle Aged,
pubmed-meshheading:17079354-Mutation,
pubmed-meshheading:17079354-Protein-Tyrosine Kinases,
pubmed-meshheading:17079354-Receptor, Epidermal Growth Factor,
pubmed-meshheading:17079354-Thyroid Neoplasms
|
|
pubmed:year |
2007
|
|
pubmed:articleTitle |
Epidermal growth factor receptor status in anaplastic thyroid carcinoma.
|
|
pubmed:affiliation |
Research Institute and Hospital, National Cancer Center, Goyang, Gyeonggi, Korea.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
