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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
7
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pubmed:dateCreated |
2006-11-2
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pubmed:abstractText |
Interleukin-12 (IL-12) is a pro-inflammatory cytokine possessing anti-cancer and anti-angiogenic properties. This study quantitatively assessed the anti-angiogenic effect of IL-12 delivered using an adenoviral vector with murine IL-12 placed under control of a heat shock promoter. This approach limits systemic toxicity by restricting IL-12 delivery locally to the tumour. The kinetics of the downstream cytokines interferon-gamma (IFN-gamma) and interferon inducible protein-10 (IP-10) and other molecules affecting angiogenesis, vascular endothelial growth factor (VEGF) and plasminogen activator inhibitor-1 (PAI-1) were also studied.
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pubmed:language |
eng
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pubmed:journal |
|
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0265-6736
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
22
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
587-606
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:17079216-Adenoviridae,
pubmed-meshheading:17079216-Angiogenesis Inhibitors,
pubmed-meshheading:17079216-Animals,
pubmed-meshheading:17079216-Chemokine CXCL10,
pubmed-meshheading:17079216-Chemokines, CXC,
pubmed-meshheading:17079216-Gene Therapy,
pubmed-meshheading:17079216-Genetic Vectors,
pubmed-meshheading:17079216-Hyperthermia, Induced,
pubmed-meshheading:17079216-Interferon-gamma,
pubmed-meshheading:17079216-Interleukin-12,
pubmed-meshheading:17079216-Lung Neoplasms,
pubmed-meshheading:17079216-Mammary Neoplasms, Animal,
pubmed-meshheading:17079216-Mice,
pubmed-meshheading:17079216-Mice, Inbred BALB C,
pubmed-meshheading:17079216-Neoplasm Metastasis,
pubmed-meshheading:17079216-Plasminogen Activator Inhibitor 1,
pubmed-meshheading:17079216-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:17079216-Vascular Endothelial Growth Factor A
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pubmed:year |
2006
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pubmed:articleTitle |
Anti-angiogenic effects of interleukin-12 delivered by a novel hyperthermia induced gene construct.
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pubmed:affiliation |
Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, CO 80523, USA. fsiddiq1@hfhs.org
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pubmed:publicationType |
Journal Article
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