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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2006-11-20
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pubmed:abstractText |
Broad antifungal structure-activity relationships governing epoxy-endoperoxides 2 and 3 and their parent endoperoxides 1 are reported. Their inhibitory activity against Candida albicans in conjunction with hemolytic activity and/or growth inhibition of cultured mammalian cells are reported. This information provided guidance for the further development of endoperoxide and epoxy-endoperoxides as topical antifungal agents.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0968-0896
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
15
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
36-42
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pubmed:meshHeading |
pubmed-meshheading:17079152-Animals,
pubmed-meshheading:17079152-Antifungal Agents,
pubmed-meshheading:17079152-CHO Cells,
pubmed-meshheading:17079152-Candida albicans,
pubmed-meshheading:17079152-Cell Proliferation,
pubmed-meshheading:17079152-Cricetinae,
pubmed-meshheading:17079152-Drug Design,
pubmed-meshheading:17079152-Erythrocytes,
pubmed-meshheading:17079152-Humans,
pubmed-meshheading:17079152-Microbial Sensitivity Tests,
pubmed-meshheading:17079152-Molecular Conformation,
pubmed-meshheading:17079152-Peroxides,
pubmed-meshheading:17079152-Stereoisomerism,
pubmed-meshheading:17079152-Structure-Activity Relationship
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pubmed:year |
2007
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pubmed:articleTitle |
Design of endoperoxides with anti-Candida activity.
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pubmed:affiliation |
Department of Chemistry, The University of Adelaide, 5005 SA, Australia.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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