Source:http://linkedlifedata.com/resource/pubmed/id/17079148
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
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| pubmed:dateCreated |
2006-11-20
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| pubmed:abstractText |
A variety of novel 3-phenyl-2-substituted-3H-quinazolin-4-ones were synthesized by reacting the amino group of 2-hydrazino-3-phenyl-3H-quinazolin-4-one with different aldehydes and ketones. The starting material 2-hydrazino-3-phenyl-3H-quinazolin-4-one was synthesized from aniline. The title compounds were investigated for analgesic, anti-inflammatory and ulcerogenic index activities. While the test compounds exhibited significant activity, compounds, 2-(N'-2-butylidene-hydrazino)-3-phenyl-3H-quinazolin-4-one (AS1), 2-(N'-3-pentylidene-hydrazino)-3-phenyl-3H-quinazolin-4-one (AS2) and 2-(N'-2-pentylidene-hydrazino)-3-phenyl-3H-quinazolin-4-one (AS3), exhibited moderate analgesic activity. The compound 2-(N'-2-pentylidene-hydrazino)-3-phenyl-3H-quinazolin-4-one (AS3) showed more potent anti-inflammatory activity when compared to the reference standard diclofenac sodium. Interestingly, the test compounds showed only mild ulcerogenic side effect when compared to aspirin.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Jan
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| pubmed:issn |
0968-0896
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:day |
1
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| pubmed:volume |
15
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
235-41
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| pubmed:meshHeading |
pubmed-meshheading:17079148-Administration, Oral,
pubmed-meshheading:17079148-Analgesics,
pubmed-meshheading:17079148-Animals,
pubmed-meshheading:17079148-Anti-Inflammatory Agents,
pubmed-meshheading:17079148-Carrageenan,
pubmed-meshheading:17079148-Dose-Response Relationship, Drug,
pubmed-meshheading:17079148-Drug Evaluation, Preclinical,
pubmed-meshheading:17079148-Female,
pubmed-meshheading:17079148-Hindlimb,
pubmed-meshheading:17079148-Inflammation,
pubmed-meshheading:17079148-Male,
pubmed-meshheading:17079148-Mice,
pubmed-meshheading:17079148-Molecular Structure,
pubmed-meshheading:17079148-Pain,
pubmed-meshheading:17079148-Quinazolinones,
pubmed-meshheading:17079148-Rats,
pubmed-meshheading:17079148-Rats, Wistar,
pubmed-meshheading:17079148-Stomach Ulcer
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| pubmed:year |
2007
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| pubmed:articleTitle |
Synthesis and pharmacological evaluation of some 3-phenyl-2-substituted-3H-quinazolin-4-one as analgesic, anti-inflammatory agents.
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| pubmed:affiliation |
Medicinal Chemistry R&D Laboratory, Arulmigu Kalasalingam College of Pharmacy, Anand Nagar, Krishnankovil-626 190, India. samy_veera@yahoo.com
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| pubmed:publicationType |
Journal Article
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