|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
5-6
|
|
pubmed:dateCreated |
2006-12-27
|
|
pubmed:abstractText |
In otherwise healthy adults, high C-reactive protein (CRP) levels are associated with cardiovascular disease and have been linked to an inflammatory state. The presence of vascular disease is also associated with increased expression of adhesion molecules, including soluble intercellular adhesion molecule (sICAM), vascular endothelial growth factor (VEGF) and leukocyte-derived myeloperoxidase (MPO). These associations suggest potential mechanisms whereby inflammation may injure the vascular endothelium, but the recognition of how these mediators act in concert remain poorly characterized. That the prevalence of atherosclerosis and markers of inflammation are increased in renal failure patients suggests that inflammation causes accelerated vascular disease.
|
|
pubmed:grant |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:issn |
0253-5068
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
24
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
508-16
|
|
pubmed:dateRevised |
2010-11-18
|
|
pubmed:meshHeading |
pubmed-meshheading:17077623-Adolescent,
pubmed-meshheading:17077623-Adult,
pubmed-meshheading:17077623-Aged,
pubmed-meshheading:17077623-Aged, 80 and over,
pubmed-meshheading:17077623-Atherosclerosis,
pubmed-meshheading:17077623-Biological Markers,
pubmed-meshheading:17077623-C-Reactive Protein,
pubmed-meshheading:17077623-Cell Adhesion Molecules,
pubmed-meshheading:17077623-Cross-Sectional Studies,
pubmed-meshheading:17077623-Female,
pubmed-meshheading:17077623-Humans,
pubmed-meshheading:17077623-Inflammation,
pubmed-meshheading:17077623-Interleukin-6,
pubmed-meshheading:17077623-Longitudinal Studies,
pubmed-meshheading:17077623-Male,
pubmed-meshheading:17077623-Middle Aged,
pubmed-meshheading:17077623-Predictive Value of Tests,
pubmed-meshheading:17077623-Renal Dialysis,
pubmed-meshheading:17077623-Renal Insufficiency,
pubmed-meshheading:17077623-Risk Factors,
pubmed-meshheading:17077623-Treatment Outcome,
pubmed-meshheading:17077623-Vascular Endothelial Growth Factor A
|
|
pubmed:year |
2006
|
|
pubmed:articleTitle |
Evidence that C-reactive protein or IL-6 are not surrogates for all inflammatory cardiovascular risk factors in hemodialysis patients.
|
|
pubmed:affiliation |
Department of Internal Medicine, Division of Nephrology, University of California, and Department of Biochemistry and Molecular Medicine, Davis, CA, USA. gakaysen@ucdavis.edu
|
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.,
Randomized Controlled Trial,
Research Support, Non-U.S. Gov't,
Multicenter Study,
Research Support, N.I.H., Extramural
|
