Linked Life Data

17076275

Source:http://linkedlifedata.com/resource/pubmed/id/17076275

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2006-11-1
pubmed:abstractText
During the entire process of neural crest development from specification till final differentiation, delamination and migration are critical steps where nascent crest cells face multiple challenges: within a relatively short period of time that does not exceed several hours, they have to change drastically their cell- and substrate-adhesion properties, lose cell polarity and activate the locomotory machinery, while keeping proliferating, surviving and maintaining a pool of precursors in the neural epithelium. Then, as soon as they are released from the neural tube, neural crest cells have to adapt to a new, rapidly-changing environment and become able to interpret multiple cues which guide them to appropriate target sites and prevent them from distributing in aberrant locations. It appears from recent studies that, behind an apparent linearity and unity, neural crest development is subdivided into several independent steps, each being governed by a multiplicity of rules and referees. Here resides probably one of the main reasons of the success of neural crest cells to accomplish their task.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:issn
0065-2598
pubmed:author
pubmed:issnType
Print
pubmed:volume
589
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
45-77
pubmed:meshHeading
pubmed:year
2006
pubmed:articleTitle
Neural crest delamination and migration: integrating regulations of cell interactions, locomotion, survival and fate.
pubmed:affiliation
Laboratoire de Biologie du Développement Centre National de la Recherche Scientifique et Université Pierre et Marie Curie 9 quai Saint-Bernard, 75005 Paris, France. duband@ccr.jussieu.fr
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't