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pubmed:abstractText |
Prefrontal dysfunction is considered a fundamental characteristic of schizophrenia. Recent electrophysiological evidence points to a major instability of signal processing in prefrontal cortical microcircuits because of reduced phase-synchronization (i.e., an increased stimulus-related variability [noise] of single-trial responses in the spatial and time domain). The authors used functional magnetic resonance imaging (fMRI) during a visual two-choice reaction task in order to measure, with higher topographic accuracy, signal stability in patients with schizophrenia and its relationship to more traditional measures of activation.
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pubmed:affiliation |
Genes, Cognition and Psychosis Program, NIH, NIMH, 10 Center Dr., MSC 1379, Bethesda, MD 20892, USA.
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