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pubmed:abstractText |
In an initial period (< or =4 h) Toll-like receptor 4 (TLR4) signaling is required for Yersinia enterocolitica YopP-induced dendritic cell (DC) death. Later (>4 h), DC die independent of TLR4 signaling. In TLR4-deficient DC caspase 8 cleavage is delayed, indicating that TLR4 signaling accelerates caspase 8 activation, leading to DC death.
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pubmed:affiliation |
Institute of Medical Microbiology and Hygiene, Eberhard Karls University of Tübingen, Elfriede-Aulhorn-Str. 6, D-72076 Tübingen, Germany. sabine.groebner@med.uni-tuebingen.de
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