Source:http://linkedlifedata.com/resource/pubmed/id/17074591
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
2006-10-31
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| pubmed:abstractText |
We present a series of 12 cases of de novo acute lymphoblastic leukemia (ALL) with translocation t(14;18)(q32;q21). The median age of patients at presentation was 65.5 years, and no patient presented with a past history or any clinical evidence of lymphoma. A Burkitt translocation was identified in 4 of the 12 cases by conventional cytogenetics but fluorescence in situ hybridization using a MYC probe identified a further three cases of MYC rearrangement: one with a cryptic t(8;14) involving the der(14)t(14;18), one showing MYC translocated onto a marker chromosome, and one associated with a t(8;9)(q24;p13) translocation. A review of the literature identified an extremely close association between the t(14;18) and the t(8;9), with the latter translocation found only in the presence of t(14;18). The present study confirms the previously reported dismal prognosis of t(14;18)-associated ALL.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Nov
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| pubmed:issn |
0165-4608
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
171
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
52-6
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| pubmed:dateRevised |
2007-11-15
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| pubmed:meshHeading |
pubmed-meshheading:17074591-Adult,
pubmed-meshheading:17074591-Aged,
pubmed-meshheading:17074591-Aged, 80 and over,
pubmed-meshheading:17074591-Antigens, CD19,
pubmed-meshheading:17074591-Antigens, CD20,
pubmed-meshheading:17074591-Antigens, CD22,
pubmed-meshheading:17074591-Chromosomes, Human, Pair 14,
pubmed-meshheading:17074591-Chromosomes, Human, Pair 18,
pubmed-meshheading:17074591-Female,
pubmed-meshheading:17074591-Humans,
pubmed-meshheading:17074591-Immunohistochemistry,
pubmed-meshheading:17074591-In Situ Hybridization, Fluorescence,
pubmed-meshheading:17074591-Karyotyping,
pubmed-meshheading:17074591-Male,
pubmed-meshheading:17074591-Middle Aged,
pubmed-meshheading:17074591-Neprilysin,
pubmed-meshheading:17074591-Precursor Cell Lymphoblastic Leukemia-Lymphoma,
pubmed-meshheading:17074591-Translocation, Genetic
|
| pubmed:year |
2006
|
| pubmed:articleTitle |
Translocation (14;18)(q32;q21) in acute lymphoblastic leukemia: a study of 12 cases and review of the literature.
|
| pubmed:affiliation |
Victorian Cancer Cytogenetics Service, St Vincent's Hospital Melbourne, Fitzroy, Victoria, Australia. pina.dachille@svhm.org.au
|
| pubmed:publicationType |
Journal Article,
Review,
Case Reports
|