Linked Life Data

17072832

Source:http://linkedlifedata.com/resource/pubmed/id/17072832

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2006-11-2
pubmed:abstractText
The distribution of retrogradely labeled spinothalamic tract (STT) neurons was analyzed in monkeys following variously sized injections of cholera toxin subunit B (CTb) in order to determine whether different STT termination sites receive input from different sets of STT cells. This report focuses on STT input to the ventral posterior lateral nucleus (VPL) and the subjacent ventral posterior inferior nucleus (VPI), where prior anterograde tracing studies identified scattered STT terminal bursts and a dense terminal field, respectively. In cases with small or medium-sized injections in VPL, labeled STT cells were located almost entirely in lamina V (in spinal segments consistent with the mediolateral VPL topography); few cells were labeled in lamina I (<8%) and essentially none in lamina VII. Large and very large injections in VPL produced marked increases in labeling in lamina I, associated first with spread into VPI and next into the posterior part of the ventral medial nucleus (VMpo), and abundant labeling in lamina VII, associated with spread into the ventral lateral (VL) nucleus. Small injections restricted to VPI labeled many STT cells in laminae I and V with an anteroposterior topography. These observations indicate that VPL receives STT input almost entirely from lamina V neurons, whereas VPI receives STT input from both laminae I and V cells, with two different topographic organizations. Together with the preceding observation that STT input to VMpo originates almost entirely from lamina I, these findings provide strong evidence that the primate STT consists of anatomically and functionally differentiable components.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0021-9967
pubmed:author
pubmed:issnType
Print
pubmed:day
20
pubmed:volume
499
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
965-78
pubmed:dateRevised
2007-12-3
pubmed:meshHeading
pubmed:year
2006
pubmed:articleTitle
Retrograde analyses of spinothalamic projections in the macaque monkey: input to ventral posterior nuclei.
pubmed:affiliation
Atkinson Research Laboratory, Barrow Neurological Institute, Phoenix, Arizona 85013, USA. bcraig@chw.edu
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural