Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2006-12-5
pubmed:abstractText
Urothelial neoplasms in patients 19 years of age or younger are rare, and the data regarding clinical outcome are conflicting. Molecular data are not available. Urothelial tumours from 14 patients aged 4 to 19 years were analysed, including FGFR3 and TP53 mutation screening, comparative genomic hybridization (CGH), UroVysion FISH analysis, polymerase chain reaction for human papillomavirus (HPV), microsatellite analysis using the NIH consensus panel for detection of microsatellite instability (MSI) and six markers for loss of heterozygosity on chromosome arms 9p, 9q, and 17p and immunohistochemistry for TP53, Ki-67, CK20 and the mismatch repair proteins (MRPs) hMSH2, hMLH1, and hMSH6. Based on the 2004 WHO classification, one urothelial papilloma, seven papillary urothelial neoplasms of low malignant potential (PUNLMPs), five low-grade, and one high-grade papillary urothelial carcinoma were included. No multifocal tumours were found and recurrence was seen in only one patient with a urothelial papilloma. All patients were alive with no evidence of disease at a median follow-up of 3.0 years. We found no mutations in FGFR3, deletions of chromosome arms 9p, 9q or 17p, MSI or MRP loss, or HPV positivity in any of the patients. Three cases showed chromosome alterations in CGH analyses, urothelial dedifferentiation with CK20 overexpression, or aneuploidy, and one TP53 mutation with TP53 overexpression was found. Urothelial neoplasms in people younger than 20 years are predominantly low grade and are associated with a favourable clinical outcome. Genetic alterations frequently seen in older adults are extremely rare in young patients. Urothelial neoplasms in children and young adults appear to be biologically distinct and lack genetic instability in most cases.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0022-3417
pubmed:author
pubmed:copyrightInfo
Copyright (c) 2006 Pathological Society of Great Britain and Ireland.
pubmed:issnType
Print
pubmed:volume
211
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
18-25
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed-meshheading:17072825-Adolescent, pubmed-meshheading:17072825-Adult, pubmed-meshheading:17072825-Alphapapillomavirus, pubmed-meshheading:17072825-Child, pubmed-meshheading:17072825-Child, Preschool, pubmed-meshheading:17072825-Chromosome Aberrations, pubmed-meshheading:17072825-Chromosomes, Human, Pair 9, pubmed-meshheading:17072825-DNA, Viral, pubmed-meshheading:17072825-DNA Mismatch Repair, pubmed-meshheading:17072825-DNA Mutational Analysis, pubmed-meshheading:17072825-Female, pubmed-meshheading:17072825-Gene Expression Profiling, pubmed-meshheading:17072825-Genes, p53, pubmed-meshheading:17072825-Humans, pubmed-meshheading:17072825-Immunohistochemistry, pubmed-meshheading:17072825-In Situ Hybridization, Fluorescence, pubmed-meshheading:17072825-Loss of Heterozygosity, pubmed-meshheading:17072825-Male, pubmed-meshheading:17072825-Microsatellite Instability, pubmed-meshheading:17072825-Oligonucleotide Array Sequence Analysis, pubmed-meshheading:17072825-Papilloma, pubmed-meshheading:17072825-Polymerase Chain Reaction, pubmed-meshheading:17072825-Receptor, Fibroblast Growth Factor, Type 3, pubmed-meshheading:17072825-Urologic Neoplasms, pubmed-meshheading:17072825-Urothelium
pubmed:year
2007
pubmed:articleTitle
Genomic aberrations are rare in urothelial neoplasms of patients 19 years or younger.
pubmed:affiliation
Institute of Pathology, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany.
pubmed:publicationType
Journal Article