Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7
pubmed:dateCreated
1991-5-6
pubmed:abstractText
Constructs expressing the core, surface, X, or polymerase proteins of hepatitis B virus were transfected into human cells. In transient assays, only the polymerase inhibited the responses to interferons alpha and gamma (IFN-alpha and -gamma). Stable expression of the polymerase was achieved in the cell line 2fTGH, which carries an IFN-inducible marker gene, by growth under conditions that select for inhibition of the response to IFN-alpha, but the clones grew poorly. When expressed alone, the terminal protein domain of the polymerase gene inhibited the response to IFN-alpha and the reverse transcriptase plus RNase H domains appeared to be toxic. Clones of cells expressing terminal protein alone, selected for the loss of response to IFN-alpha, grew normally and had no detectable response to IFN-alpha, IFN-gamma, or double-stranded RNA. Binding of IFN-alpha to these cells was not impaired but did not lead to activation of the E alpha subunit of the IFN-induced transcription factor E. These observations are of potential importance in relation to the pathogenesis of chronic hepatitis B virus infection and the resistance of such infection to IFN-alpha therapy.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/1707174, http://linkedlifedata.com/resource/pubmed/commentcorrection/1707174-1690862, http://linkedlifedata.com/resource/pubmed/commentcorrection/1707174-1696158, http://linkedlifedata.com/resource/pubmed/commentcorrection/1707174-171316, http://linkedlifedata.com/resource/pubmed/commentcorrection/1707174-1901407, http://linkedlifedata.com/resource/pubmed/commentcorrection/1707174-2098113, http://linkedlifedata.com/resource/pubmed/commentcorrection/1707174-2104683, http://linkedlifedata.com/resource/pubmed/commentcorrection/1707174-2123539, http://linkedlifedata.com/resource/pubmed/commentcorrection/1707174-2153938, http://linkedlifedata.com/resource/pubmed/commentcorrection/1707174-2154703, http://linkedlifedata.com/resource/pubmed/commentcorrection/1707174-2156225, http://linkedlifedata.com/resource/pubmed/commentcorrection/1707174-2164611, http://linkedlifedata.com/resource/pubmed/commentcorrection/1707174-2332517, http://linkedlifedata.com/resource/pubmed/commentcorrection/1707174-2342456, http://linkedlifedata.com/resource/pubmed/commentcorrection/1707174-2422321, http://linkedlifedata.com/resource/pubmed/commentcorrection/1707174-2423427, http://linkedlifedata.com/resource/pubmed/commentcorrection/1707174-2441659, http://linkedlifedata.com/resource/pubmed/commentcorrection/1707174-2447293, http://linkedlifedata.com/resource/pubmed/commentcorrection/1707174-2461895, http://linkedlifedata.com/resource/pubmed/commentcorrection/1707174-2478362, http://linkedlifedata.com/resource/pubmed/commentcorrection/1707174-2501084, http://linkedlifedata.com/resource/pubmed/commentcorrection/1707174-2513475, http://linkedlifedata.com/resource/pubmed/commentcorrection/1707174-2542615, http://linkedlifedata.com/resource/pubmed/commentcorrection/1707174-2606351, http://linkedlifedata.com/resource/pubmed/commentcorrection/1707174-2721502, http://linkedlifedata.com/resource/pubmed/commentcorrection/1707174-2829171, http://linkedlifedata.com/resource/pubmed/commentcorrection/1707174-2847156, http://linkedlifedata.com/resource/pubmed/commentcorrection/1707174-2854056, http://linkedlifedata.com/resource/pubmed/commentcorrection/1707174-2919169, http://linkedlifedata.com/resource/pubmed/commentcorrection/1707174-2995835, http://linkedlifedata.com/resource/pubmed/commentcorrection/1707174-3039907, http://linkedlifedata.com/resource/pubmed/commentcorrection/1707174-3158718, http://linkedlifedata.com/resource/pubmed/commentcorrection/1707174-3359997, http://linkedlifedata.com/resource/pubmed/commentcorrection/1707174-6180680, http://linkedlifedata.com/resource/pubmed/commentcorrection/1707174-6218412, http://linkedlifedata.com/resource/pubmed/commentcorrection/1707174-6928559, http://linkedlifedata.com/resource/pubmed/commentcorrection/1707174-7175502
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0027-8424
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
88
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2888-92
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1991
pubmed:articleTitle
Expression of the terminal protein region of hepatitis B virus inhibits cellular responses to interferons alpha and gamma and double-stranded RNA.
pubmed:affiliation
Imperial Cancer Research Fund, Lincoln's Inn Fields, London, United Kingdom.
pubmed:publicationType
Journal Article