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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2007-3-30
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pubmed:abstractText |
The caspase proteins are essential for the regulation of normal B cell development and regulation of apoptosis. We investigated five single nucleotide polymorphisms in four key caspase genes, CASP3 [Ex8-280C>A (rs6948) and Ex8+567T>C (rs1049216)], CASP8 Ex14-271A>T (rs13113), CASP9 Ex5+32G>A (rs1052576) and CASP10 Ex3-171A>G (rs3900115) to determine whether they alter risk for non-Hodgkin lymphoma (NHL) in a population-based case-control study of women in Connecticut (461 cases and 535 controls). Variants in CASP3 and CASP9 were significantly associated with a decreased risk for NHL, particularly follicular lymphoma [e.g. CASP3 Ex8+567T>C odds ratio (OR)(CC+TC) = 0.4, 95% confidence interval (CI) = 0.3-0.7; and CASP9 Ex5+32G>A OR(AA+AG) = 0.6, 95% CI = 0.4-1.0]. Further, variants in CASP3, CASP8 and CASP10 were associated with a decreased risk of marginal zone lymphoma and variants in CASP3 and CASP10 were associated with a lower risk of chronic lymphocytic leukemia and related subtypes. The striking protective associations observed for polymorphisms in all four genes for NHL and/or one or more subtypes suggest that genetic variation in CASP genes may play an important role in the etiology of NHL.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/CASP10 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/CASP3 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/CASP8 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/CASP9 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Caspase 10,
http://linkedlifedata.com/resource/pubmed/chemical/Caspase 3,
http://linkedlifedata.com/resource/pubmed/chemical/Caspase 8,
http://linkedlifedata.com/resource/pubmed/chemical/Caspase 9
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0143-3334
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pubmed:author |
pubmed-author:BerndtSonja ISI,
pubmed-author:BoylePeterP,
pubmed-author:ChanockStephenS,
pubmed-author:HolfordTheodore RTR,
pubmed-author:HosgoodDeanD,
pubmed-author:LanQingQ,
pubmed-author:LeadererBrianB,
pubmed-author:RothmanNathanielN,
pubmed-author:ShenMinM,
pubmed-author:WangSophia SSS,
pubmed-author:WelchRobertR,
pubmed-author:YeagerMeredithM,
pubmed-author:ZahmShelia HSH,
pubmed-author:ZhangYaweiY,
pubmed-author:ZhengTongzhangT
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pubmed:issnType |
Print
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pubmed:volume |
28
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
823-7
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:17071630-Adult,
pubmed-meshheading:17071630-Aged,
pubmed-meshheading:17071630-Aged, 80 and over,
pubmed-meshheading:17071630-Case-Control Studies,
pubmed-meshheading:17071630-Caspase 10,
pubmed-meshheading:17071630-Caspase 3,
pubmed-meshheading:17071630-Caspase 8,
pubmed-meshheading:17071630-Caspase 9,
pubmed-meshheading:17071630-DNA Repair,
pubmed-meshheading:17071630-Female,
pubmed-meshheading:17071630-Genetic Predisposition to Disease,
pubmed-meshheading:17071630-Genetic Variation,
pubmed-meshheading:17071630-Humans,
pubmed-meshheading:17071630-Lymphoma, Non-Hodgkin,
pubmed-meshheading:17071630-Middle Aged,
pubmed-meshheading:17071630-Polymorphism, Single Nucleotide,
pubmed-meshheading:17071630-Risk Factors
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pubmed:year |
2007
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pubmed:articleTitle |
Genetic variants in caspase genes and susceptibility to non-Hodgkin lymphoma.
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pubmed:affiliation |
Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute NIH, DHHS, Bethesda, MD 20892-7240, USA. qingl@mail.nih.gov
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, N.I.H., Extramural,
Research Support, N.I.H., Intramural
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