Source:http://linkedlifedata.com/resource/pubmed/id/17070967
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
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pubmed:dateCreated |
2007-2-26
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pubmed:abstractText |
The substituted pyridazino[4,5-b]phenazine-5,12-diones and tri/tetra-azabenzo[a]fluorene-5,6-diones were synthesized from 6,7-dichlorophthalazine-5,8-dione and 6,7-dichloroquinoline-5,8-dione, respectively. The cytotoxic activities of the prepared compounds were evaluated by an SRB (Sulforhodamine B) assay against the following human cancer cell lines: A549 (lung), SK-OV-3 (ovarian), SK-MEL-2 (melanoma), XF 498 (CNS), and HCT 15 (colon). Almost all synthesized pyridazino[4,5-b]phenazine-5,12-diones (7a-j) presented higher cytotoxicity than that of doxorubicin (IC(50)=0.097-0.225 microM) against the cancer cell lines. In particular, the cytotoxicity of compounds 7f (R(1)=Et) and 7h (R(1), R(2)=Me) against all human cancer cell lines examined was about 10 times higher than that of doxorubicin. However, the cytotoxicities of several synthesized azabenzo[a]fluorene-5,6-diones (12a, 12c, 12d, 12e, and 12g) against the cancer cell lines in vitro were comparable to those of doxorubicin.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0223-5234
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pubmed:author |
pubmed-author:KimChoonmiC,
pubmed-author:KimHwa JungHJ,
pubmed-author:KimJin SungJS,
pubmed-author:LeeChong-OckCO,
pubmed-author:LeeHyun-JungHJ,
pubmed-author:LeeSang KookSK,
pubmed-author:Park ChooHea-YoungHY,
pubmed-author:ParkHyen JooHJ,
pubmed-author:RheeHee-KyungHK,
pubmed-author:SeoEun-KyungEK,
pubmed-author:SuhMyung-EunME
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pubmed:issnType |
Print
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pubmed:volume |
42
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
168-74
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pubmed:meshHeading |
pubmed-meshheading:17070967-Antineoplastic Agents,
pubmed-meshheading:17070967-Cell Line, Tumor,
pubmed-meshheading:17070967-Drug Screening Assays, Antitumor,
pubmed-meshheading:17070967-Fluorenes,
pubmed-meshheading:17070967-Humans,
pubmed-meshheading:17070967-Phenazines,
pubmed-meshheading:17070967-Pyridazines,
pubmed-meshheading:17070967-Structure-Activity Relationship
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pubmed:year |
2007
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pubmed:articleTitle |
Synthesis and cytotoxicity evaluation of substituted pyridazino[4,5-b]phenazine-5,12-diones and tri/tetra-azabenzofluorene-5,6-diones.
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pubmed:affiliation |
School of Pharmacy, Ewha Womans University, 11-1 Daehyun-Dong Seodaemun-Ku, Seoul 120-750, South Korea.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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