Source:http://linkedlifedata.com/resource/pubmed/id/17070059
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
2006-11-20
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pubmed:abstractText |
A series of pyrazino[2,1-b]isoquinoline and 6,15-iminoisoquino[3,2-b]-3-benzazocine compounds related to renieramycins, cribrostatin 4, and phthalascidin was synthesized and their in vitro cytotoxic activities were evaluated against three human cancer cell lines. Pyrazino[2,1-b]isoquinolines, 6,15-iminoisoquino[3,2-b]-3-benzazocines, and other more complex octacyclic compounds have been obtained and derived to precursors of iminium ion species. Hydrogenolysis of the lactam function in pentacyclic compounds gave 1-(3-isoquinolyl)isoquinolines. The micromolar cytotoxic activity of representative structures was apparently uninfluenced by the ability to generate intermediates which would permit covalent bonding to DNA.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0968-0896
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
15
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
112-8
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pubmed:meshHeading |
pubmed-meshheading:17070059-Azocines,
pubmed-meshheading:17070059-Cell Line, Tumor,
pubmed-meshheading:17070059-Cell Proliferation,
pubmed-meshheading:17070059-Colonic Neoplasms,
pubmed-meshheading:17070059-Drug Screening Assays, Antitumor,
pubmed-meshheading:17070059-Humans,
pubmed-meshheading:17070059-Isoquinolines,
pubmed-meshheading:17070059-Lung Neoplasms,
pubmed-meshheading:17070059-Molecular Conformation,
pubmed-meshheading:17070059-Pyrazines,
pubmed-meshheading:17070059-Stereoisomerism,
pubmed-meshheading:17070059-Structure-Activity Relationship,
pubmed-meshheading:17070059-Tumor Cells, Cultured
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pubmed:year |
2007
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pubmed:articleTitle |
Synthesis and cytotoxic activity of pyrazino[1,2-b]-isoquinolines, 1-(3-isoquinolyl)isoquinolines, and 6,15-iminoisoquino[3,2-b]-3-benzazocines.
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pubmed:affiliation |
Departamento de Química Orgánica y Farmacéutica, Facultad de Farmacia, Universidad Complutense, 28040 Madrid, Spain.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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