Linked Life Data

17069562

Source:http://linkedlifedata.com/resource/pubmed/id/17069562

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
Pt 3
pubmed:dateCreated
2007-4-19
pubmed:abstractText
S100A8, the light subunit of calprotectin, has been known to be associated with periodontal inflammation. The present study looked to detect whether three polymorphisms in the upstream region of the S100A8 gene are correlated with periodontitis. Three hundred and twenty one subjects, including chronic periodontitis (CP) patients, aggressive periodontitis (AgP) patients and periodontally healthy controls, were recruited. The SNPs rs3795391, rs3806232 and rs3885688 were analyzed by PCR-RFLP analysis. No person carried the rs3885688 polymorphism in this cohort. For the other two polymorphisms, the combined effects of genotype/allele and gender were shown to be associated with the risk of periodontitis using multivariate logistic regression analysis. The G+ genotype/G allele may be considered to exert a significant protective effect in males against AgP (Genotype: rs3795391: P= 0.032, rs3806232: P= 0.017; Allele: rs3795391: P= 0.024, rs3806232: P= 0.013). Although the combined effects of genotype and gender on CP susceptibility were not observed for these two polymorphisms, there does seem to be increased risk of CP in males with allele A compared to females with allele A (rs3795391: P= 0.008; rs3806232: P= 0.009). Hence we found an important association between polymorphisms in the S100A8 gene and periodontitis in a Chinese population.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0003-4800
pubmed:author
pubmed:issnType
Print
pubmed:volume
71
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
312-24
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
Correlation between single nucleotide polymorphisms in a calprotectin subunit gene and risk of periodontitis in a Chinese population.
pubmed:affiliation
Department of Periodontology, School of Stomatology, Peking University, 22 Zhong Guan Cun Nan Da Jie, Beijing 100081, P. R. China.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't