Source:http://linkedlifedata.com/resource/pubmed/id/17067796
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
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pubmed:dateCreated |
2007-1-15
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pubmed:abstractText |
To understand the effects of a novel butyrolactone derivative, 3-benzyl-5-((2-nitrophenoxy) methyl)-dihydrofuran-2(3H)-one (3BDO), on the apoptosis of vascular endothelial cells (VECs), we exposed 3BDO (20-60 microg/ml) to VECs deprived of serum and FGF-2 for 24 and 48 h, respectively. The results showed that 3BDO (20-60 microg/ml) increased VEC viability and inhibited VEC apoptosis induced by deprivation of serum and FGF-2 in a very weak dose-dependent manner. During this process, integrin beta4 expression was depressed, but the level of reactive oxygen species (ROS) was not changed. The data suggested that 3BDO (20-60 microg/ml) could inhibit VEC apoptosis and suppress integrin beta4 expression, but it could not depress the ROS level induced by deprivation of serum and FGF-2.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0960-894X
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
17
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
482-5
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pubmed:meshHeading |
pubmed-meshheading:17067796-4-Butyrolactone,
pubmed-meshheading:17067796-Apoptosis,
pubmed-meshheading:17067796-DNA,
pubmed-meshheading:17067796-DNA Fragmentation,
pubmed-meshheading:17067796-Endothelial Cells,
pubmed-meshheading:17067796-Endothelium, Vascular,
pubmed-meshheading:17067796-In Situ Nick-End Labeling,
pubmed-meshheading:17067796-Integrin beta4,
pubmed-meshheading:17067796-Reactive Oxygen Species
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pubmed:year |
2007
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pubmed:articleTitle |
A novel butyrolactone derivative inhibited apoptosis and depressed integrin beta4 expression in vascular endothelial cells.
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pubmed:affiliation |
Institute of Developmental Biology, School of Life Science, Shandong University, Jinan 250100, China.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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