rdf:type |
|
lifeskim:mentions |
|
pubmed:issue |
5
|
pubmed:dateCreated |
2006-11-20
|
pubmed:abstractText |
High-throughput gene expression profiling has recently shown that the mRNA for alpha-methylacyl CoA racemase (AMACR or P504S) is overexpressed in prostate carcinomas (PCa). Several immunohistochemical studies have reported the usefulness of anti-AMACR/P504S for detecting prostate cancer over the full range of prostate specimens encountered in surgical pathology. We tested real-time reverse transcriptase-polymerase chain reaction (RT-PCR) for specific and sensitive detection of AMACR transcripts as a supplementary measure for discriminating between malignant and benign lesions in prostatic tissues.
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:issn |
0361-090X
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:volume |
30
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
449-54
|
pubmed:meshHeading |
pubmed-meshheading:17067752-Adenocarcinoma,
pubmed-meshheading:17067752-Fluorescence,
pubmed-meshheading:17067752-Humans,
pubmed-meshheading:17067752-Kinetics,
pubmed-meshheading:17067752-Male,
pubmed-meshheading:17067752-Prostatectomy,
pubmed-meshheading:17067752-Prostatic Hyperplasia,
pubmed-meshheading:17067752-Prostatic Neoplasms,
pubmed-meshheading:17067752-RNA, Messenger,
pubmed-meshheading:17067752-RNA, Neoplasm,
pubmed-meshheading:17067752-ROC Curve,
pubmed-meshheading:17067752-Racemases and Epimerases,
pubmed-meshheading:17067752-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:17067752-Sensitivity and Specificity,
pubmed-meshheading:17067752-Tumor Markers, Biological
|
pubmed:year |
2006
|
pubmed:articleTitle |
Kinetic fluorescence reverse transcriptase-polymerase chain reaction for alpha-methylacyl CoA racemase distinguishes prostate cancer from benign lesions.
|
pubmed:affiliation |
Department of Urology, Charité-Campus Benjamin Franklin, Universitätsmedizin Berlin, Germany. martin.schostak@charite.de
|
pubmed:publicationType |
Journal Article,
Comparative Study
|