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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
11
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pubmed:dateCreated |
2006-10-27
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pubmed:abstractText |
The activity of adenylyl cyclase (AC) is enhanced by pharmacologically relevant concentrations of ethanol. The enhancing effect of ethanol on AC activity is AC isoform-specific. Therefore, we hypothesized that within a cyclic AMP-generating system, AC is the target of ethanol's action and that ethanol-sensitive AC molecules contain structural elements modulated by ethanol. The structural elements are designated as "ethanol responsive domains."
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0145-6008
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
30
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1824-32
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pubmed:dateRevised |
2011-3-11
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pubmed:meshHeading |
pubmed-meshheading:17067346-Adenylate Cyclase,
pubmed-meshheading:17067346-Cells, Cultured,
pubmed-meshheading:17067346-Central Nervous System Depressants,
pubmed-meshheading:17067346-Cyclic AMP,
pubmed-meshheading:17067346-DNA, Complementary,
pubmed-meshheading:17067346-Ethanol,
pubmed-meshheading:17067346-Humans,
pubmed-meshheading:17067346-Isoenzymes,
pubmed-meshheading:17067346-Models, Molecular,
pubmed-meshheading:17067346-Molecular Sequence Data,
pubmed-meshheading:17067346-Mutant Chimeric Proteins,
pubmed-meshheading:17067346-Mutation,
pubmed-meshheading:17067346-Signal Transduction,
pubmed-meshheading:17067346-Transfection
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pubmed:year |
2006
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pubmed:articleTitle |
Identification of ethanol responsive domains of adenylyl cyclase.
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pubmed:affiliation |
Department of Pharmacology, University of Colorado Health Sciences Center, Aurora, CO, USA. myoshimura@vetmed.lsu.edu
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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