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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2006-10-27
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pubmed:abstractText |
Injection of the same antigen following primary immunization induces a classic secondary response characterized by a large quantity of high-affinity antibody of an immunoglobulin G class produced more rapidly than in the initial response - the products of memory B cells are qualitatively distinct from that of the original naive B lymphocytes. Very little is known of the help provided by the CD4 T cells that stimulate memory B cells. Using antigen-specific T-cell receptor transgenic CD4 T cells (DO11.10) as a source of help, we found that naive transgenic T cells stimulated memory B cells almost as well (in terms of quantity and speed) as transgenic T cells that had been recently primed. There was a direct correlation between serum antibody levels and the number of naive transgenic T cells transferred. Using T cells from transgenic interleukin-2-deficient mice we showed that interleukin-2 was not required for a secondary response, although it was necessary for a primary response. The results suggested that the signals delivered by CD4 T cells and required by memory B cells for their activation were common to both antigen-primed and naive CD4 T cells.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/17067314-10072535,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17067314-10358774,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17067314-10430625,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17067314-10485652,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17067314-10537110,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17067314-10580495,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17067314-10639425,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17067314-10679068,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17067314-10779756,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17067314-1083300,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/17067314-10903764,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/17067314-1834163,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17067314-1902502,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17067314-1978253,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17067314-3493076,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17067314-4110524,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17067314-4229,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17067314-4357185,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/17067314-7589122,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17067314-7682232,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17067314-7889419,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17067314-7957551,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17067314-8145034,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17067314-8235625,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17067314-8600537,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/17067314-9176700,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17067314-9405263,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17067314-9432980,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17067314-9547331,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17067314-9590217,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17067314-9597129,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17067314-9651253,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17067314-9743552,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17067314-9794390,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17067314-9916697
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0019-2805
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
119
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
376-84
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:17067314-Animals,
pubmed-meshheading:17067314-Mice,
pubmed-meshheading:17067314-Ovalbumin,
pubmed-meshheading:17067314-Lymphocyte Transfusion,
pubmed-meshheading:17067314-Antibody Formation,
pubmed-meshheading:17067314-Mice, Inbred BALB C,
pubmed-meshheading:17067314-Immunologic Memory,
pubmed-meshheading:17067314-B-Lymphocytes,
pubmed-meshheading:17067314-Models, Immunological,
pubmed-meshheading:17067314-T-Lymphocyte Subsets,
pubmed-meshheading:17067314-Lymphocyte Cooperation,
pubmed-meshheading:17067314-Interleukin-2,
pubmed-meshheading:17067314-CD4-Positive T-Lymphocytes,
pubmed-meshheading:17067314-Mice, SCID
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