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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2006-10-27
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pubmed:abstractText |
Systemic lupus erythematosus (SLE) is an autoimmune disease resulting from dysregulation of the immune system. Interleukin-6 (IL-6) is a multifunctional cytokine produced by macrophages, monocytes and T and B cells. It stimulates B-cell differentiation/maturation, immunoglobulin secretion, and T-cell functions. Elevated levels of IL-6 in serum, urine and renal glomeruli were detected in patients with active SLE and in murine models of SLE. Our study investigated the role of IL-6 in an SLE-like disease in New Zealand Black/White (NZB/W) F1 mice by administration of an anti-murine IL-6 monoclonal antibody (mAb). Intraperitoneal administration of the anti-IL-6 mAb suppressed the production of anti-dsDNA autoantibody. B-cell proliferation induced by anti-IgM and anti-CD40 was lower in the anti-IL-6 mAb-treated mice, ex vivo studies demonstrated that anti-IL-6 mAb treatment inhibited anti-dsDNA production. Anti-CD3-induced T-cell proliferation and mixed lymphocyte reactions were inhibited by anti-IL-6 mAb treatment, indicating a partial down-regulation of T cells. Histological analysis showed that treatment with anti-IL-6 mAb prevented the development of severe kidney disease. These results suggest that treatment with anti-IL-6 mAb has a beneficial effect on autoimmunity in murine SLE and that autoreactive B cells may be the primary target for anti-IL-6 mAb treatment; its effect on autoreactive T cells is also indicated.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/17067309-10193432,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17067309-10446862,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17067309-10485648,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17067309-10851053,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17067309-11748261,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17067309-12220549,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17067309-14499117,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17067309-14717922,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17067309-15187153,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17067309-15225360,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17067309-15230289,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17067309-15771564,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17067309-15934843,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17067309-16648838,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17067309-2051017,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17067309-8040314,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17067309-9620640,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17067309-9649207,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17067309-9653168,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17067309-9862671
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0019-2805
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
119
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
296-305
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:17067309-Animals,
pubmed-meshheading:17067309-Antibodies, Antinuclear,
pubmed-meshheading:17067309-Antibodies, Monoclonal,
pubmed-meshheading:17067309-Autoimmune Diseases,
pubmed-meshheading:17067309-B-Lymphocytes,
pubmed-meshheading:17067309-DNA,
pubmed-meshheading:17067309-Disease Models, Animal,
pubmed-meshheading:17067309-Disease Progression,
pubmed-meshheading:17067309-Interleukin-6,
pubmed-meshheading:17067309-Lupus Erythematosus, Systemic,
pubmed-meshheading:17067309-Lupus Nephritis,
pubmed-meshheading:17067309-Lymphocyte Activation,
pubmed-meshheading:17067309-Mice,
pubmed-meshheading:17067309-Mice, Inbred NZB,
pubmed-meshheading:17067309-STAT3 Transcription Factor,
pubmed-meshheading:17067309-Serum Amyloid A Protein,
pubmed-meshheading:17067309-Severity of Illness Index,
pubmed-meshheading:17067309-T-Lymphocyte Subsets
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pubmed:year |
2006
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pubmed:articleTitle |
Anti-interleukin-6 monoclonal antibody inhibits autoimmune responses in a murine model of systemic lupus erythematosus.
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pubmed:affiliation |
Immunobiology, Centocor, Radnor, PA, USA. bliang1@cntus.jnj.com
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pubmed:publicationType |
Journal Article
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